Signaling in lymphocyte activation

TY - JOUR

T1 - Signaling in lymphocyte activation

AU - Cantrell, Doreen

PY - 2015/6

Y1 - 2015/6

N2 - The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.

AB - The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.

UR - https://www.scopus.com/pages/publications/84930440481

U2 - 10.1101/cshperspect.a018788

DO - 10.1101/cshperspect.a018788

M3 - Article

C2 - 26032717

AN - SCOPUS:84930440481

SN - 1943-0264

VL - 7

JO - Cold spring harbor perspectives in biology

JF - Cold spring harbor perspectives in biology

IS - 6

M1 - a018788

ER -