Silencing metabolic disorders by novel SIRT1 activators

Kei Sakamoto

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.
    Original languageEnglish
    Pages (from-to)3-4
    Number of pages2
    JournalCell Metabolism
    Issue number1
    Publication statusPublished - 2008


    • Animals
    • Antioxidants
    • Humans
    • Metabolic Diseases
    • Models, Biological
    • Sirtuin 1
    • Sirtuins
    • Stilbenes


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