Silencing metabolic disorders by novel SIRT1 activators

Kei Sakamoto

doi:10.1016/j.cmet.2007.12.005

Silencing metabolic disorders by novel SIRT1 activators

Kei Sakamoto

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.

Original language	English
Pages (from-to)	3-4
Number of pages	2
Journal	Cell Metabolism
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2007.12.005
Publication status	Published - 2008

Keywords

Animals
Antioxidants
Humans
Metabolic Diseases
Models, Biological
Sirtuin 1
Sirtuins
Stilbenes

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10.1016/j.cmet.2007.12.005

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title = "Silencing metabolic disorders by novel SIRT1 activators",

abstract = "SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.",

keywords = "Animals, Antioxidants, Humans, Metabolic Diseases, Models, Biological, Sirtuin 1, Sirtuins, Stilbenes",

author = "Kei Sakamoto",

year = "2008",

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language = "English",

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AU - Sakamoto, Kei

PY - 2008

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AB - SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.

KW - Animals

KW - Antioxidants

KW - Humans

KW - Metabolic Diseases

KW - Models, Biological

KW - Sirtuin 1

KW - Sirtuins

KW - Stilbenes

U2 - 10.1016/j.cmet.2007.12.005

DO - 10.1016/j.cmet.2007.12.005

M3 - Article

C2 - 18177718

SN - 1550-4131

VL - 7

SP - 3

EP - 4

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Silencing metabolic disorders by novel SIRT1 activators

Abstract

Keywords

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