Simplification of Care for Chronic Hepatitis C Virus Infection

Jean-Michel Pawlotsky (Lead / Corresponding author), Christian B. Ramers, John F. Dillon, Jordan J. Feld, Jeffrey V. Lazarus

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)
44 Downloads (Pure)


In 2016, the World Health Organization (WHO) set a target for eliminating viral hepatitis as a major public health threat by 2030. However, while today's highly effective and well-tolerated pangenotypic direct-acting antiviral regimens have maximized simplification of hepatitis C virus (HCV) treatment, there remain a plethora of barriers to HCV screening, diagnosis, and linkage to care. As of 2017, only 19% of the estimated 71 million individuals living with chronic HCV worldwide were diagnosed and in 2015 to 2016, only 21% of diagnosed individuals had accessed treatment. Simplification and decentralization of the HCV care cascade would bolster patient engagement and support the considerable scale-up needed to achieve WHO targets. Recent developments in HCV screening and diagnosis, together with reduced pretreatment assessment and on-treatment monitoring requirements, can further streamline the care continuum, ensuring patients are linked to care quickly and earlier in the disease course, and minimize clinic visits.

Original languageEnglish
Pages (from-to)392-402
Number of pages11
JournalSeminars in Liver Disease
Issue number4
Early online date28 Jul 2020
Publication statusPublished - 1 Nov 2020


  • care cascade
  • diagnosis
  • hepatitis C virus
  • screening
  • treatment

ASJC Scopus subject areas

  • Hepatology


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