Simulation of intra-aneurysmal blood flow by different numerical methods

Frank Weichert (Lead / Corresponding author), Lars Walczak, Denis Fisseler, Tobias Opfermann, Mudassar Razzaq, Raphael Münster, Stefan Turek, Iris Grunwald, Christian Roth, Christian Veith, Mathias Wagner

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The occlusional performance of sole endoluminal stenting of intracranial aneurysms is controversially discussed in the literature. Simulation of blood flow has been studied to shed light on possible causal attributions. The outcome, however, largely depends on the numerical method and various free parameters. The present study is therefore conducted to find ways to define parameters and efficiently explore the huge parameter space with finite element methods (FEMs) and lattice Boltzmann methods (LBMs). The goal is to identify both the impact of different parameters on the results of computational fluid dynamics (CFD) and their advantages and disadvantages. CFD is applied to assess flow and aneurysmal vorticity in 2D and 3D models. To assess and compare initial simulation results, simplified 2D and 3D models based on key features of real geometries and medical expert knowledge were used. A result obtained from this analysis indicates that a combined use of the different numerical methods, LBM for fast exploration and FEM for a more in-depth look, may result in a better understanding of blood flow and may also lead to more accurate information about factors that influence conditions for stenting of intracranial aneurysms.

Original languageEnglish
Article number527654
Number of pages11
JournalComputational and mathematical methods in medicine
Publication statusPublished - 15 Apr 2013


  • Cerebrovascular Circulation
  • Computational Biology
  • Finite Element Analysis
  • Humans
  • Hydrodynamics
  • Imaging, Three-Dimensional
  • Intracranial Aneurysm/physiopathology
  • Models, Cardiovascular
  • Regional Blood Flow
  • Stents


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