Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

Daniel Menzies, Arun Nair, Karen T. Meldrum, Dawn Fleming, Martyn Barnes, Brian J. Lipworth

    Research output: Contribution to journalArticle

    105 Citations (Scopus)

    Abstract

    Statins lower cholesterol and also exhibit anti-inflammatory properties. In vitro and animal studies have suggested they may be useful for the treatment of a number of inflammatory conditions.
    Original languageEnglish
    Pages (from-to)328-335
    Number of pages8
    JournalJournal of Allergy and Clinical Immunology
    Volume119
    Issue number2
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Simvastatin
    Anti-Inflammatory Agents
    Asthma
    Cholesterol
    Therapeutics
    In Vitro Techniques

    Keywords

    • Adult
    • Anti-Inflammatory Agents
    • Asthma
    • Cross-Over Studies
    • Double-Blind Method
    • Female
    • Humans
    • Hydroxymethylglutaryl-CoA Reductase Inhibitors
    • Male
    • Middle Aged
    • Nitric Oxide
    • Simvastatin
    • Th1 Cells
    • Th2 Cells

    Cite this

    Menzies, Daniel ; Nair, Arun ; Meldrum, Karen T. ; Fleming, Dawn ; Barnes, Martyn ; Lipworth, Brian J. / Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma. In: Journal of Allergy and Clinical Immunology. 2007 ; Vol. 119, No. 2. pp. 328-335.
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    author = "Daniel Menzies and Arun Nair and Meldrum, {Karen T.} and Dawn Fleming and Martyn Barnes and Lipworth, {Brian J.}",
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    Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma. / Menzies, Daniel; Nair, Arun; Meldrum, Karen T.; Fleming, Dawn; Barnes, Martyn; Lipworth, Brian J.

    In: Journal of Allergy and Clinical Immunology, Vol. 119, No. 2, 2007, p. 328-335.

    Research output: Contribution to journalArticle

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    AU - Menzies, Daniel

    AU - Nair, Arun

    AU - Meldrum, Karen T.

    AU - Fleming, Dawn

    AU - Barnes, Martyn

    AU - Lipworth, Brian J.

    PY - 2007

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    KW - Double-Blind Method

    KW - Female

    KW - Humans

    KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

    KW - Male

    KW - Middle Aged

    KW - Nitric Oxide

    KW - Simvastatin

    KW - Th1 Cells

    KW - Th2 Cells

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