Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

Daniel Menzies; Arun Nair; Karen T. Meldrum; Dawn Fleming; Martyn Barnes; Brian J. Lipworth

doi:10.1016/j.jaci.2006.10.014

Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

Daniel Menzies, Arun Nair, Karen T. Meldrum, Dawn Fleming, Martyn Barnes, Brian J. Lipworth

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

Statins lower cholesterol and also exhibit anti-inflammatory properties. In vitro and animal studies have suggested they may be useful for the treatment of a number of inflammatory conditions.

Original language	English
Pages (from-to)	328-335
Number of pages	8
Journal	Journal of Allergy and Clinical Immunology
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2006.10.014
Publication status	Published - 2007

Keywords

Adult
Anti-Inflammatory Agents
Asthma
Cross-Over Studies
Double-Blind Method
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Male
Middle Aged
Nitric Oxide
Simvastatin
Th1 Cells
Th2 Cells

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10.1016/j.jaci.2006.10.014

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title = "Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma",

abstract = "Statins lower cholesterol and also exhibit anti-inflammatory properties. In vitro and animal studies have suggested they may be useful for the treatment of a number of inflammatory conditions.",

keywords = "Adult, Anti-Inflammatory Agents, Asthma, Cross-Over Studies, Double-Blind Method, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Nitric Oxide, Simvastatin, Th1 Cells, Th2 Cells",

author = "Daniel Menzies and Arun Nair and Meldrum, {Karen T.} and Dawn Fleming and Martyn Barnes and Lipworth, {Brian J.}",

year = "2007",

doi = "10.1016/j.jaci.2006.10.014",

language = "English",

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pages = "328--335",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

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T1 - Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

AU - Menzies, Daniel

AU - Nair, Arun

AU - Meldrum, Karen T.

AU - Fleming, Dawn

AU - Barnes, Martyn

AU - Lipworth, Brian J.

PY - 2007

Y1 - 2007

N2 - Statins lower cholesterol and also exhibit anti-inflammatory properties. In vitro and animal studies have suggested they may be useful for the treatment of a number of inflammatory conditions.

AB - Statins lower cholesterol and also exhibit anti-inflammatory properties. In vitro and animal studies have suggested they may be useful for the treatment of a number of inflammatory conditions.

KW - Adult

KW - Anti-Inflammatory Agents

KW - Asthma

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Male

KW - Middle Aged

KW - Nitric Oxide

KW - Simvastatin

KW - Th1 Cells

KW - Th2 Cells

U2 - 10.1016/j.jaci.2006.10.014

DO - 10.1016/j.jaci.2006.10.014

M3 - Article

C2 - 17141851

SN - 0091-6749

VL - 119

SP - 328

EP - 335

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 2

ER -

Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

Abstract

Keywords

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