Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

Daniel Menzies, Arun Nair, Karen T. Meldrum, Dawn Fleming, Martyn Barnes, Brian J. Lipworth

    Research output: Contribution to journalArticle

    109 Citations (Scopus)

    Abstract

    Statins lower cholesterol and also exhibit anti-inflammatory properties. In vitro and animal studies have suggested they may be useful for the treatment of a number of inflammatory conditions.
    Original languageEnglish
    Pages (from-to)328-335
    Number of pages8
    JournalJournal of Allergy and Clinical Immunology
    Volume119
    Issue number2
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Adult
    • Anti-Inflammatory Agents
    • Asthma
    • Cross-Over Studies
    • Double-Blind Method
    • Female
    • Humans
    • Hydroxymethylglutaryl-CoA Reductase Inhibitors
    • Male
    • Middle Aged
    • Nitric Oxide
    • Simvastatin
    • Th1 Cells
    • Th2 Cells

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