Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

María Soler Artigas, Louise V. Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ioanna Ntalla, Nick Shrine, Ma'en Obeidat, Holly Trochet, Wendy L. McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K. Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M. Lopez, Jonathan MartenStefan Enroth, Ida Surakka, Ozren Polasek, Leo Pekka Lyytikäinen, Raquel Granell, Pirro G. Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R. González, Harald Grallert, Chris J. Hammond, Sarah E. Harris, Anna Liisa Hartikainen, Markku Heliövaara, John Henderson, Lynne Hocking, Momoko Horikoshi, Nina Hutri-Kähönen, Erik Ingelsson, Åsa Johansson, John P. Kemp, Ivana Kolcic, Ashish Kumar, Andrew P. Morris, UK BiLEVE

    Research output: Contribution to journalArticlepeer-review

    55 Citations (Scopus)
    112 Downloads (Pure)

    Abstract

    Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

    Original languageEnglish
    Article number89658
    Number of pages12
    JournalNature Communications
    Volume6
    DOIs
    Publication statusPublished - 4 Dec 2015

    Fingerprint Dive into the research topics of 'Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation'. Together they form a unique fingerprint.

    Cite this