Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

María Soler Artigas; Louise V. Wain; Suzanne Miller; Abdul Kader Kheirallah; Jennifer E. Huffman; Ioanna Ntalla; Nick Shrine; Ma'en Obeidat; Holly Trochet; Wendy L. McArdle; Alexessander Couto Alves; Jennie Hui; Jing Hua Zhao; Peter K. Joshi; Alexander Teumer; Eva Albrecht; Medea Imboden; Rajesh Rawal; Lorna M. Lopez; Jonathan Marten; Stefan Enroth; Ida Surakka; Ozren Polasek; Leo Pekka Lyytikäinen; Raquel Granell; Pirro G. Hysi; Claudia Flexeder; Anubha Mahajan; John Beilby; Yohan Bossé; Corry Anke Brandsma; Harry Campbell; Christian Gieger; Sven Gläser; Juan R. González; Harald Grallert; Chris J. Hammond; Sarah E. Harris; Anna Liisa Hartikainen; Markku Heliövaara; John Henderson; Lynne Hocking; Momoko Horikoshi; Nina Hutri-Kähönen; Erik Ingelsson; Åsa Johansson; John P. Kemp; Ivana Kolcic; Ashish Kumar; Andrew P. Morris; UK BiLEVE

doi:10.1038/ncomms9658

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

María Soler Artigas, Louise V. Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ioanna Ntalla, Nick Shrine, Ma'en Obeidat, Holly Trochet, Wendy L. McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K. Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M. Lopez, Jonathan MartenStefan Enroth, Ida Surakka, Ozren Polasek, Leo Pekka Lyytikäinen, Raquel Granell, Pirro G. Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R. González, Harald Grallert, Chris J. Hammond, Sarah E. Harris, Anna Liisa Hartikainen, Markku Heliövaara, John Henderson, Lynne Hocking, Momoko Horikoshi, Nina Hutri-Kähönen, Erik Ingelsson, Åsa Johansson, John P. Kemp, Ivana Kolcic, Ashish Kumar, Andrew P. Morris, UK BiLEVE

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Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC) and FEV₁/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10^-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Original language	English
Article number	89658
Number of pages	12
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms9658
Publication status	Published - 4 Dec 2015

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Chemistry(all)
Physics and Astronomy(all)

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Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M., Trochet, H., McArdle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., Lopez, L. M., ... UK BiLEVE (2015). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, Article 89658. https://doi.org/10.1038/ncomms9658

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title = "Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation",

abstract = "Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.",

author = "Artigas, {Mar{\'i}a Soler} and Wain, {Louise V.} and Suzanne Miller and Kheirallah, {Abdul Kader} and Huffman, {Jennifer E.} and Ioanna Ntalla and Nick Shrine and Ma'en Obeidat and Holly Trochet and McArdle, {Wendy L.} and Alves, {Alexessander Couto} and Jennie Hui and Zhao, {Jing Hua} and Joshi, {Peter K.} and Alexander Teumer and Eva Albrecht and Medea Imboden and Rajesh Rawal and Lopez, {Lorna M.} and Jonathan Marten and Stefan Enroth and Ida Surakka and Ozren Polasek and Lyytik{\"a}inen, {Leo Pekka} and Raquel Granell and Hysi, {Pirro G.} and Claudia Flexeder and Anubha Mahajan and John Beilby and Yohan Boss{\'e} and Brandsma, {Corry Anke} and Harry Campbell and Christian Gieger and Sven Gl{\"a}ser and Gonz{\'a}lez, {Juan R.} and Harald Grallert and Hammond, {Chris J.} and Harris, {Sarah E.} and Hartikainen, {Anna Liisa} and Markku Heli{\"o}vaara and John Henderson and Lynne Hocking and Momoko Horikoshi and Nina Hutri-K{\"a}h{\"o}nen and Erik Ingelsson and {\AA}sa Johansson and Kemp, {John P.} and Ivana Kolcic and Ashish Kumar and Morris, {Andrew P.} and {UK BiLEVE}",

year = "2015",

month = dec,

day = "4",

doi = "10.1038/ncomms9658",

language = "English",

volume = "6",

journal = "Nature Communications",

issn = "2041-1723",

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}

Artigas, MS, Wain, LV, Miller, S, Kheirallah, AK, Huffman, JE, Ntalla, I, Shrine, N, Obeidat, M, Trochet, H, McArdle, WL, Alves, AC, Hui, J, Zhao, JH, Joshi, PK, Teumer, A, Albrecht, E, Imboden, M, Rawal, R, Lopez, LM, Marten, J, Enroth, S, Surakka, I, Polasek, O, Lyytikäinen, LP, Granell, R, Hysi, PG, Flexeder, C, Mahajan, A, Beilby, J, Bossé, Y, Brandsma, CA, Campbell, H, Gieger, C, Gläser, S, González, JR, Grallert, H, Hammond, CJ, Harris, SE, Hartikainen, AL, Heliövaara, M, Henderson, J, Hocking, L, Horikoshi, M, Hutri-Kähönen, N, Ingelsson, E, Johansson, Å, Kemp, JP, Kolcic, I, Kumar, A, Morris, AP & UK BiLEVE 2015, 'Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation', Nature Communications, vol. 6, 89658. https://doi.org/10.1038/ncomms9658

TY - JOUR

T1 - Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

AU - Artigas, María Soler

AU - Wain, Louise V.

AU - Miller, Suzanne

AU - Kheirallah, Abdul Kader

AU - Huffman, Jennifer E.

AU - Ntalla, Ioanna

AU - Shrine, Nick

AU - Obeidat, Ma'en

AU - Trochet, Holly

AU - McArdle, Wendy L.

AU - Alves, Alexessander Couto

AU - Hui, Jennie

AU - Zhao, Jing Hua

AU - Joshi, Peter K.

AU - Teumer, Alexander

AU - Albrecht, Eva

AU - Imboden, Medea

AU - Rawal, Rajesh

AU - Lopez, Lorna M.

AU - Marten, Jonathan

AU - Enroth, Stefan

AU - Surakka, Ida

AU - Polasek, Ozren

AU - Lyytikäinen, Leo Pekka

AU - Granell, Raquel

AU - Hysi, Pirro G.

AU - Flexeder, Claudia

AU - Mahajan, Anubha

AU - Beilby, John

AU - Bossé, Yohan

AU - Brandsma, Corry Anke

AU - Campbell, Harry

AU - Gieger, Christian

AU - Gläser, Sven

AU - González, Juan R.

AU - Grallert, Harald

AU - Hammond, Chris J.

AU - Harris, Sarah E.

AU - Hartikainen, Anna Liisa

AU - Heliövaara, Markku

AU - Henderson, John

AU - Hocking, Lynne

AU - Horikoshi, Momoko

AU - Hutri-Kähönen, Nina

AU - Ingelsson, Erik

AU - Johansson, Åsa

AU - Kemp, John P.

AU - Kolcic, Ivana

AU - Kumar, Ashish

AU - Morris, Andrew P.

AU - UK BiLEVE

PY - 2015/12/4

Y1 - 2015/12/4

N2 - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

AB - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

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U2 - 10.1038/ncomms9658

DO - 10.1038/ncomms9658

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SN - 2041-1723

VL - 6

JO - Nature Communications

JF - Nature Communications

M1 - 89658

ER -

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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