Sleep maintains excitatory synapse diversity in the cortex and hippocampus

Dimitra Koukaroudi, Zhen Qiu, Erik Fransén, Ragini Gokhale, Edita Bulovaite, Noboru H. Komiyama, Julie Seibt, Seth G.N. Grant (Lead / Corresponding author)

Research output: Working paper/PreprintPreprint

18 Downloads (Pure)

Abstract

How sleep deprivation affects cognition remains elusive. Synaptome mapping of excitatory synapses in 125 regions of the mouse brain revealed that sleep deprivation selectively reduces synapse diversity in the cortex and hippocampus. Sleep deprivation targeted specific types and subtypes of excitatory synapses while maintaining total synapse density. Altered synaptic responses to neural oscillations in a computational model suggest that sleep prevents cognitive impairments by maintaining normal brain synaptome architecture.
Original languageEnglish
PublisherBioRxiv
Number of pages23
DOIs
Publication statusPublished - 19 Jul 2023

Fingerprint

Dive into the research topics of 'Sleep maintains excitatory synapse diversity in the cortex and hippocampus'. Together they form a unique fingerprint.

Cite this