Small molecules can have big effects on endurance

Keith Baar, D. Grahame Hardie

    Research output: Contribution to journalComment/debate

    2 Citations (Scopus)

    Abstract

    Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.

    Original languageEnglish
    Pages (from-to)583-584
    Number of pages3
    JournalNature Chemical Biology
    Volume4
    Issue number10
    DOIs
    Publication statusPublished - Oct 2008

    Keywords

    • CHRONIC ACTIVATION
    • SKELETAL-MUSCLE
    • GLYCOGEN
    • AMPK

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