Small molecules can have big effects on endurance

Keith Baar; D. Grahame Hardie

doi:10.1038/nchembio1008-583

Small molecules can have big effects on endurance

Keith Baar
, D. Grahame Hardie

Research output: Contribution to journal › Comment/debate › peer-review

2 Citations (Scopus)

Abstract

Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.

Original language	English
Pages (from-to)	583-584
Number of pages	3
Journal	Nature Chemical Biology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1038/nchembio1008-583
Publication status	Published - Oct 2008

Keywords

CHRONIC ACTIVATION
SKELETAL-MUSCLE
GLYCOGEN
AMPK

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title = "Small molecules can have big effects on endurance",

abstract = "Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.",

keywords = "CHRONIC ACTIVATION, SKELETAL-MUSCLE, GLYCOGEN, AMPK",

author = "Keith Baar and Hardie, \{D. Grahame\}",

year = "2008",

month = oct,

doi = "10.1038/nchembio1008-583",

language = "English",

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AU - Baar, Keith

AU - Hardie, D. Grahame

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AB - Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.

KW - CHRONIC ACTIVATION

KW - SKELETAL-MUSCLE

KW - GLYCOGEN

KW - AMPK

U2 - 10.1038/nchembio1008-583

DO - 10.1038/nchembio1008-583

M3 - Comment/debate

C2 - 18800044

SN - 1552-4450

VL - 4

SP - 583

EP - 584

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 10

ER -

Small molecules can have big effects on endurance

Abstract

Keywords

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