Small RNAs derived from the 5' end of tRNA can inhibit protein translation in human cells

Andrew Sobala, Gyorgy Hutvagner (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    125 Citations (Scopus)


    Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5' and 3' termini. To date, the function of these tRNA fragments (tRFs) derived from the 5' end of tRNA has not been investigated in depth. We present evidence that conserved residues in tRNA, present in all 5' tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5' tRFs in a new mechanism of gene regulation by small RNAs in human cells.
    Original languageEnglish
    Pages (from-to)553-563
    Number of pages11
    JournalRNA Biology
    Issue number4
    Publication statusPublished - Apr 2013



    • Argonaute Proteins
    • Gene Expression Regulation
    • Genes, Reporter
    • HeLa Cells
    • Humans
    • MicroRNAs
    • Protein Biosynthesis
    • RNA, Messenger
    • RNA, Small Untranslated
    • RNA, Transfer
    • Transfection

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