Smoking, haemostatic factors and lipid peroxides in a population case control study of peripheral arterial disease

F. B. Smith, G. D.O. Lowe, F. G.R. Fowkes (Lead / Corresponding author), A. Rumley, A. G. Rumley, P. T. Donnan, E. Housley

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The aim of this study was to determine differences between cases of peripheral arterial disease and healthy controls in levels of haemostatic factors and lipid peroxides and the influence of cigarette smoking. The study groups were selected from the Edinburgh Artery Study which is a random sample survey of men and women aged 55-74 years. Mean levels of plasma fibrinogen, von Willebrand factor, β-thromboglobulin, plasminogen activator inhibitor (type I), cross-linked fibrin degradation products and lipid peroxides were markedly elevated in 121 study cases compared with 126 age- and sex-matched controls. For example, cross-linked fibrin degradation products had a geometric mean of 106.8 ng/ml (95% confidence interval (CI) 95.3, 119.8) in study cases and 74.7 ng/ml (95% CI 67.0, 83.4) in controls (P < 0.001). Inclusion of smoking in logistic regressions of each factor on peripheral arterial disease significantly reduced the odds of disease for von Willebrand factor and for cross-linked fibrin degradation products, but had little effect on the increased odds associated with fibrinogen, β-thromboglobulin, plasminogen activator inhibitor and lipid peroxides. We conclude that, in men and women in Edinburgh, peripheral atherosclerosis is associated with lipid peroxidation, endothelial disturbance, platelet activation, elevated fibrinogen, fibrin formation and increased inhibition of fibrinolysis. The most important effects of cigarette smoking in promoting atherosclerosis may be endothelial disturbance and fibrin formation.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalAtherosclerosis
Volume102
Issue number2
DOIs
Publication statusPublished - 1 Jan 1993

Fingerprint

Fibrin Fibrinogen Degradation Products
Population Control
Lipid Peroxides
Peripheral Arterial Disease
Hemostatics
Fibrinogen
Case-Control Studies
Plasminogen Inactivators
Smoking
von Willebrand Factor
Fibrin
Atherosclerosis
Confidence Intervals
Platelet Activation
Fibrinolysis
Lipid Peroxidation
Arteries
Logistic Models

Keywords

  • Endothelium
  • Fibrinogen
  • Fibrinolysis
  • Lipid peroxides
  • Peripheral atherosclerosis
  • Smoking

Cite this

Smith, F. B. ; Lowe, G. D.O. ; Fowkes, F. G.R. ; Rumley, A. ; Rumley, A. G. ; Donnan, P. T. ; Housley, E. / Smoking, haemostatic factors and lipid peroxides in a population case control study of peripheral arterial disease. In: Atherosclerosis. 1993 ; Vol. 102, No. 2. pp. 155-162.
@article{2808e534783241779eed00e5b61a4fdb,
title = "Smoking, haemostatic factors and lipid peroxides in a population case control study of peripheral arterial disease",
abstract = "The aim of this study was to determine differences between cases of peripheral arterial disease and healthy controls in levels of haemostatic factors and lipid peroxides and the influence of cigarette smoking. The study groups were selected from the Edinburgh Artery Study which is a random sample survey of men and women aged 55-74 years. Mean levels of plasma fibrinogen, von Willebrand factor, β-thromboglobulin, plasminogen activator inhibitor (type I), cross-linked fibrin degradation products and lipid peroxides were markedly elevated in 121 study cases compared with 126 age- and sex-matched controls. For example, cross-linked fibrin degradation products had a geometric mean of 106.8 ng/ml (95{\%} confidence interval (CI) 95.3, 119.8) in study cases and 74.7 ng/ml (95{\%} CI 67.0, 83.4) in controls (P < 0.001). Inclusion of smoking in logistic regressions of each factor on peripheral arterial disease significantly reduced the odds of disease for von Willebrand factor and for cross-linked fibrin degradation products, but had little effect on the increased odds associated with fibrinogen, β-thromboglobulin, plasminogen activator inhibitor and lipid peroxides. We conclude that, in men and women in Edinburgh, peripheral atherosclerosis is associated with lipid peroxidation, endothelial disturbance, platelet activation, elevated fibrinogen, fibrin formation and increased inhibition of fibrinolysis. The most important effects of cigarette smoking in promoting atherosclerosis may be endothelial disturbance and fibrin formation.",
keywords = "Endothelium, Fibrinogen, Fibrinolysis, Lipid peroxides, Peripheral atherosclerosis, Smoking",
author = "Smith, {F. B.} and Lowe, {G. D.O.} and Fowkes, {F. G.R.} and A. Rumley and Rumley, {A. G.} and Donnan, {P. T.} and E. Housley",
year = "1993",
month = "1",
day = "1",
doi = "10.1016/0021-9150(93)90157-P",
language = "English",
volume = "102",
pages = "155--162",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier",
number = "2",

}

Smoking, haemostatic factors and lipid peroxides in a population case control study of peripheral arterial disease. / Smith, F. B.; Lowe, G. D.O.; Fowkes, F. G.R. (Lead / Corresponding author); Rumley, A.; Rumley, A. G.; Donnan, P. T.; Housley, E.

In: Atherosclerosis, Vol. 102, No. 2, 01.01.1993, p. 155-162.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Smoking, haemostatic factors and lipid peroxides in a population case control study of peripheral arterial disease

AU - Smith, F. B.

AU - Lowe, G. D.O.

AU - Fowkes, F. G.R.

AU - Rumley, A.

AU - Rumley, A. G.

AU - Donnan, P. T.

AU - Housley, E.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The aim of this study was to determine differences between cases of peripheral arterial disease and healthy controls in levels of haemostatic factors and lipid peroxides and the influence of cigarette smoking. The study groups were selected from the Edinburgh Artery Study which is a random sample survey of men and women aged 55-74 years. Mean levels of plasma fibrinogen, von Willebrand factor, β-thromboglobulin, plasminogen activator inhibitor (type I), cross-linked fibrin degradation products and lipid peroxides were markedly elevated in 121 study cases compared with 126 age- and sex-matched controls. For example, cross-linked fibrin degradation products had a geometric mean of 106.8 ng/ml (95% confidence interval (CI) 95.3, 119.8) in study cases and 74.7 ng/ml (95% CI 67.0, 83.4) in controls (P < 0.001). Inclusion of smoking in logistic regressions of each factor on peripheral arterial disease significantly reduced the odds of disease for von Willebrand factor and for cross-linked fibrin degradation products, but had little effect on the increased odds associated with fibrinogen, β-thromboglobulin, plasminogen activator inhibitor and lipid peroxides. We conclude that, in men and women in Edinburgh, peripheral atherosclerosis is associated with lipid peroxidation, endothelial disturbance, platelet activation, elevated fibrinogen, fibrin formation and increased inhibition of fibrinolysis. The most important effects of cigarette smoking in promoting atherosclerosis may be endothelial disturbance and fibrin formation.

AB - The aim of this study was to determine differences between cases of peripheral arterial disease and healthy controls in levels of haemostatic factors and lipid peroxides and the influence of cigarette smoking. The study groups were selected from the Edinburgh Artery Study which is a random sample survey of men and women aged 55-74 years. Mean levels of plasma fibrinogen, von Willebrand factor, β-thromboglobulin, plasminogen activator inhibitor (type I), cross-linked fibrin degradation products and lipid peroxides were markedly elevated in 121 study cases compared with 126 age- and sex-matched controls. For example, cross-linked fibrin degradation products had a geometric mean of 106.8 ng/ml (95% confidence interval (CI) 95.3, 119.8) in study cases and 74.7 ng/ml (95% CI 67.0, 83.4) in controls (P < 0.001). Inclusion of smoking in logistic regressions of each factor on peripheral arterial disease significantly reduced the odds of disease for von Willebrand factor and for cross-linked fibrin degradation products, but had little effect on the increased odds associated with fibrinogen, β-thromboglobulin, plasminogen activator inhibitor and lipid peroxides. We conclude that, in men and women in Edinburgh, peripheral atherosclerosis is associated with lipid peroxidation, endothelial disturbance, platelet activation, elevated fibrinogen, fibrin formation and increased inhibition of fibrinolysis. The most important effects of cigarette smoking in promoting atherosclerosis may be endothelial disturbance and fibrin formation.

KW - Endothelium

KW - Fibrinogen

KW - Fibrinolysis

KW - Lipid peroxides

KW - Peripheral atherosclerosis

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=0027367043&partnerID=8YFLogxK

U2 - 10.1016/0021-9150(93)90157-P

DO - 10.1016/0021-9150(93)90157-P

M3 - Article

VL - 102

SP - 155

EP - 162

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -