SnapShot: Types of ubiquitin ligases

Francesca Ester Morreale; Helen Walden

doi:10.1016/j.cell.2016.03.003

SnapShot: Types of ubiquitin ligases

Francesca Ester Morreale, Helen Walden

MRC PPU

Research output: Contribution to journal › Article › peer-review

332 Citations (Scopus)

Abstract

Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.

Original language	English
Pages (from-to)	248-248.e1
Number of pages	2
Journal	Cell
Volume	165
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2016.03.003
Publication status	Published - 24 Mar 2016

Keywords

Animals
Humans
Protein processing, Post-Translational
Proteins
Ubiquitin-conjugating enzymes
Ubiquitination
Journal article

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10.1016/j.cell.2016.03.003

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KW - Humans

KW - Protein processing, Post-Translational

KW - Proteins

KW - Ubiquitin-conjugating enzymes

KW - Ubiquitination

KW - Journal article

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DO - 10.1016/j.cell.2016.03.003

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SnapShot: Types of ubiquitin ligases

Abstract

Keywords

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