SnapShot: Types of ubiquitin ligases

Francesca Ester Morreale, Helen Walden

Research output: Contribution to journalArticlepeer-review

301 Citations (Scopus)


Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.

Original languageEnglish
Pages (from-to)248-248.e1
Number of pages2
Issue number1
Publication statusPublished - 24 Mar 2016


  • Animals
  • Humans
  • Protein processing, Post-Translational
  • Proteins
  • Ubiquitin-conjugating enzymes
  • Ubiquitination
  • Journal article


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