Snf2-family proteins: chromatin remodellers for any occasion

Daniel P. Ryan, Tom Owen-Hughes

    Research output: Contribution to journalReview article

    59 Citations (Scopus)

    Abstract

    Chromatin facilitates the housing of eukaryotic DNA within the nucleus and restricts access to the underlying sequences. Thus, the regulation of chromatin structure provides an excellent platform for regulating processes that require information stored within genomic DNA. Snf2 proteins are a family of helicase-like proteins that direct energy derived from ATP hydrolysis into the mechanical remodelling of chromatin structure. Here, we highlight some of the recent discoveries regarding this family of proteins and show Snf2 proteins have roles in many aspects of genetic metabolism. Recent developments include new insights into the mechanism for nucleosome spacing and histone dimer exchange; together with growing evidence for the involvement of Snf2 proteins in DNA repair.

    Original languageEnglish
    Pages (from-to)649-656
    Number of pages8
    JournalCurrent Opinion in Chemical Biology
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - Oct 2011

    Keywords

    • STRAND BREAK REPAIR
    • DNA-DAMAGE
    • SACCHAROMYCES-CEREVISIAE
    • HISTONE CHAPERONE
    • CRYSTAL-STRUCTURE
    • FACTOR CHD4
    • COMPLEXES
    • REPLICATION
    • NUCLEOSOME
    • ENZYME

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