SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

Makiko Fujii; Lyudmila A. Lyakh; Cameron P. Bracken; Junya Fukuoka; Morisada Hayakawa; Tadasuke Tsukiyama; Steven J. Soll; Melissa Harris; Sonia Rocha; Kevin C. Roche; Shin-ichi Tominaga; Jin Jen; Neil D. Perkins; Robert J. Lechleider; Anita B. Roberts

doi:10.1016/j.molcel.2006.11.006

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

Makiko Fujii, Lyudmila A. Lyakh, Cameron P. Bracken, Junya Fukuoka, Morisada Hayakawa, Tadasuke Tsukiyama, Steven J. Soll, Melissa Harris, Sonia Rocha, Kevin C. Roche, Shin-ichi Tominaga, Jin Jen, Neil D. Perkins, Robert J. Lechleider, Anita B. Roberts

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and transformation. We demonstrate that SNIP1 functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc both by stabilizing it against proteosomal degradation and by bridging the c-Myc/p300 complex. These effects of SNIP1 on c-Myc likely contribute to synergistic effects of SNIP1, c-Myc, and H-Ras in inducing formation of foci in an in vitro transformation assay and also in supporting anchorage-independent growth. The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis.

Original language	English
Pages (from-to)	771-83
Number of pages	13
Journal	Molecular Cell
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2006.11.006
Publication status	Published - 8 Dec 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.molcel.2006.11.006

Cite this

Fujii, M., Lyakh, L. A., Bracken, C. P., Fukuoka, J., Hayakawa, M., Tsukiyama, T., Soll, S. J., Harris, M., Rocha, S., Roche, K. C., Tominaga, S., Jen, J., Perkins, N. D., Lechleider, R. J., & Roberts, A. B. (2006). SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Molecular Cell, 24(5), 771-83. https://doi.org/10.1016/j.molcel.2006.11.006

@article{9af0b41105f24417a060660c754a7e02,

title = "SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes",

abstract = "Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and transformation. We demonstrate that SNIP1 functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc both by stabilizing it against proteosomal degradation and by bridging the c-Myc/p300 complex. These effects of SNIP1 on c-Myc likely contribute to synergistic effects of SNIP1, c-Myc, and H-Ras in inducing formation of foci in an in vitro transformation assay and also in supporting anchorage-independent growth. The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis.",

author = "Makiko Fujii and Lyakh, {Lyudmila A.} and Bracken, {Cameron P.} and Junya Fukuoka and Morisada Hayakawa and Tadasuke Tsukiyama and Soll, {Steven J.} and Melissa Harris and Sonia Rocha and Roche, {Kevin C.} and Shin-ichi Tominaga and Jin Jen and Perkins, {Neil D.} and Lechleider, {Robert J.} and Roberts, {Anita B.}",

year = "2006",

month = dec,

day = "8",

doi = "10.1016/j.molcel.2006.11.006",

language = "English",

volume = "24",

pages = "771--83",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Elsevier",

number = "5",

}

Fujii, M, Lyakh, LA, Bracken, CP, Fukuoka, J, Hayakawa, M, Tsukiyama, T, Soll, SJ, Harris, M, Rocha, S, Roche, KC, Tominaga, S, Jen, J, Perkins, ND, Lechleider, RJ & Roberts, AB 2006, 'SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes', Molecular Cell, vol. 24, no. 5, pp. 771-83. https://doi.org/10.1016/j.molcel.2006.11.006

TY - JOUR

T1 - SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

AU - Fujii, Makiko

AU - Lyakh, Lyudmila A.

AU - Bracken, Cameron P.

AU - Fukuoka, Junya

AU - Hayakawa, Morisada

AU - Tsukiyama, Tadasuke

AU - Soll, Steven J.

AU - Harris, Melissa

AU - Rocha, Sonia

AU - Roche, Kevin C.

AU - Tominaga, Shin-ichi

AU - Jen, Jin

AU - Perkins, Neil D.

AU - Lechleider, Robert J.

AU - Roberts, Anita B.

PY - 2006/12/8

Y1 - 2006/12/8

N2 - Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and transformation. We demonstrate that SNIP1 functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc both by stabilizing it against proteosomal degradation and by bridging the c-Myc/p300 complex. These effects of SNIP1 on c-Myc likely contribute to synergistic effects of SNIP1, c-Myc, and H-Ras in inducing formation of foci in an in vitro transformation assay and also in supporting anchorage-independent growth. The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis.

AB - Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and transformation. We demonstrate that SNIP1 functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc both by stabilizing it against proteosomal degradation and by bridging the c-Myc/p300 complex. These effects of SNIP1 on c-Myc likely contribute to synergistic effects of SNIP1, c-Myc, and H-Ras in inducing formation of foci in an in vitro transformation assay and also in supporting anchorage-independent growth. The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis.

U2 - 10.1016/j.molcel.2006.11.006

DO - 10.1016/j.molcel.2006.11.006

M3 - Article

C2 - 17157259

SN - 1097-2765

VL - 24

SP - 771

EP - 783

JO - Molecular Cell

JF - Molecular Cell

IS - 5

ER -

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this