Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 863-878 |
| Number of pages | 16 |
| Journal | Molecular Microbiology |
| Volume | 110 |
| Issue number | 6 |
| Early online date | 14 Sep 2018 |
| DOIs | |
| Publication status | Published - 1 Dec 2018 |
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Keywords
- Bacillus subtilis
- quorum sensing
- nanotubes
- electrical signalling kin‐selection
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Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond. / Kalamara, Margarita; Špacapan, Mihael ; Mandic‐Mulec, Ines (Lead / Corresponding author); Stanley-Wall, Nicola (Lead / Corresponding author).
In: Molecular Microbiology, Vol. 110, No. 6, 01.12.2018, p. 863-878.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond
AU - Kalamara, Margarita
AU - Špacapan, Mihael
AU - Mandic‐Mulec, Ines
AU - Stanley-Wall, Nicola
N1 - Work in the NSW laboratory is supported by the Biotechnology and Biological Sciences Research Council [BB/P001335/1; BB/R012415/1]. Work in the IMM laboratory is supported by the Slovenian research agency program grant P4-0116, the J4-7637 grant for fundamental research and the young researcher grant awarded to MŠ. We thank Prof Akos Kovacs for his helpful input."
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Here we review the multiple mechanisms that the Gram‐positive bacterium Bacillus subtilis uses to allow it to communicate between cells and establish community structures. The modes of action that are used are highly varied and include routes that sense pheromone levels during quorum sensing and control gene regulation, the intimate coupling of cells via nanotubes to share cytoplasmic contents, and long range electrical signalling to couple metabolic processes both within and between biofilms. We explore the ability of B. subtilis to detect “kin” (and “cheater cells”) by looking at the mechanisms used to potentially ensure beneficial sharing (or limit exploitation) of extracellular “public goods”. Finally reflecting on the array of methods that a single bacterium has at its disposal to ensure maximal benefit for its progeny, we highlight that a large future challenge will be integrating how these systems interact in mixed species communities.
AB - Here we review the multiple mechanisms that the Gram‐positive bacterium Bacillus subtilis uses to allow it to communicate between cells and establish community structures. The modes of action that are used are highly varied and include routes that sense pheromone levels during quorum sensing and control gene regulation, the intimate coupling of cells via nanotubes to share cytoplasmic contents, and long range electrical signalling to couple metabolic processes both within and between biofilms. We explore the ability of B. subtilis to detect “kin” (and “cheater cells”) by looking at the mechanisms used to potentially ensure beneficial sharing (or limit exploitation) of extracellular “public goods”. Finally reflecting on the array of methods that a single bacterium has at its disposal to ensure maximal benefit for its progeny, we highlight that a large future challenge will be integrating how these systems interact in mixed species communities.
KW - Bacillus subtilis
KW - quorum sensing
KW - nanotubes
KW - electrical signalling kin‐selection
UR - http://www.scopus.com/inward/record.url?scp=85055949862&partnerID=8YFLogxK
U2 - 10.1111/mmi.14127
DO - 10.1111/mmi.14127
M3 - Review article
C2 - 30218468
VL - 110
SP - 863
EP - 878
JO - Molecular Microbiology
JF - Molecular Microbiology
SN - 0950-382X
IS - 6
ER -