Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

Keyphrases

• Side Chain 100%
• Chitin Synthesis Inhibitor 100%
• Argifin 100%
• Solid-phase Synthesis 100%
• Cyclic Peptide 100%
• Natural Products 66%
• Deprotection 66%
• High Efficiency 33%
• Resin 33%
• Family 18 chitinase 33%
• N-methylation 33%
• Cyclization 33%
• All-solid 33%
• X-ray Structure 33%
• Derivatization 33%
• Cyclic Pentapeptide 33%
• Aspartimide 33%
• Fmoc-SPPS 33%
• Solid Support 33%
• Acidolysis 33%
• Polypeptide Chain 33%
• Representative Family 33%
• Linear Peptide 33%
• Carbamoyl 33%
• On-resin 33%
• Side Reactions 33%

Chemistry

• Cyclic Peptide 100%
• Natural Product 100%
• Derivatization 50%
• Pentapeptide 50%
• Carbamoyl 50%
• Acidolysis 50%
• Peptide 50%
• Arginine 50%

Biochemistry, Genetics and Molecular Biology

• Chitinase 100%
• Solid Phase Synthesis 100%
• Cyclic Peptide 100%
• X Ray 33%
• Derivatization 33%
• Arginine 33%
• Peptide 33%