Solid phase synthesis of purines from pyrimidines

Raffaella Di Lucrezia, Ian H. Gilbert, Christopher D. Floyd

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)


    In this paper the solid phase synthesis of various substituted purines is described starting from 4,6-dichloro-5-nitropyrimidine, The 4,6-dichloro-5-nitropyrimidine was coupled to Rink amide resin followed by displacement of the second chloride by an amino compound. Reduction of the nitro compound proved to be problematic but was achieved using lithium aluminum hydride/aluminum trichloride. The diamines (13) were then elaborated to purines by three different routes.

    Original languageEnglish
    Pages (from-to)249-253
    Number of pages5
    JournalJournal of Combinatorial Chemistry
    Issue number3
    Publication statusPublished - 2000


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