Solid phase synthesis of purines from pyrimidines

Raffaella Di Lucrezia, Ian H. Gilbert, Christopher D. Floyd

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    Abstract

    In this paper the solid phase synthesis of various substituted purines is described starting from 4,6-dichloro-5-nitropyrimidine, The 4,6-dichloro-5-nitropyrimidine was coupled to Rink amide resin followed by displacement of the second chloride by an amino compound. Reduction of the nitro compound proved to be problematic but was achieved using lithium aluminum hydride/aluminum trichloride. The diamines (13) were then elaborated to purines by three different routes.

    Original languageEnglish
    Pages (from-to)249-253
    Number of pages5
    JournalJournal of Combinatorial Chemistry
    Volume2
    Issue number3
    DOIs
    Publication statusPublished - 2000

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