Some problems and errors in cytogenetic biodosimetry

Irma Mosse, Alexander Kilchevsky, Nevena Nikolova, Nikolai Zhelev (Lead / Corresponding author)

Research output: Contribution to journalReview article

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Abstract

Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2–3 standard deviations). Thus, the same dose of radiation may result in different levels of genotoxic damage (commonly measured as chromosome aberration rates) in different individuals. There is significant genetic component in individual radiosensitivity. It is related to carriership of variant alleles of various single-nucleotide polymorphisms (most of these in genes coding for proteins functioning in DNA damage identification and repair); carriership of a different number of alleles producing cumulative effects; amplification of gene copies coding for proteins responsible for radioresistance, mobile genetic elements and others. Among the other factors influencing individual radioresistance are: the radioadaptive response; the bystander effect; the levels of endogenous substances with radioprotective and antimutagenic properties and environmental factors such as lifestyle and diet, physical activity, psychoemotional state, hormonal state, certain drugs, infections and others. These factors may have radioprotective or sensibilizing effects. Apparently, there are too many factors that may significantly modulate the biological effects of ionizing radiation. Thus, conventional methodologies for biodosimetry (specifically, cytogenetic methods) may produce significant errors if personal traits that may affect radioresistance are not accounted for.

Original languageEnglish
Pages (from-to)460-468
Number of pages9
JournalBiotechnology and Biotechnological Equipment
Volume31
Issue number3
Early online date14 Dec 2016
DOIs
Publication statusPublished - 4 May 2017

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Radiation Tolerance
Cytogenetics
Alleles
Binomial Distribution
Interspersed Repetitive Sequences
Bystander Effect
Gene Amplification
Ionizing Radiation
Chromosome Aberrations
DNA Repair
DNA Damage
Single Nucleotide Polymorphism
Life Style
Proteins
Radiation
Diet
Infection
Pharmaceutical Preparations

Keywords

  • Biodosimetry errors
  • environmental factors
  • genetic variation
  • radiosensitivity

Cite this

Mosse, Irma ; Kilchevsky, Alexander ; Nikolova, Nevena ; Zhelev, Nikolai. / Some problems and errors in cytogenetic biodosimetry. In: Biotechnology and Biotechnological Equipment. 2017 ; Vol. 31, No. 3. pp. 460-468.
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Some problems and errors in cytogenetic biodosimetry. / Mosse, Irma; Kilchevsky, Alexander; Nikolova, Nevena; Zhelev, Nikolai (Lead / Corresponding author).

In: Biotechnology and Biotechnological Equipment, Vol. 31, No. 3, 04.05.2017, p. 460-468.

Research output: Contribution to journalReview article

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