Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Toshiya Nishi
, Shinichi Kondo
, Maki Miyamoto
, Sayuri Watanabe
, Shigeo Hasegawa
, Shigeru Kondo
, Jason Yano
, Etsurou Watanabe
, Tsuyoshi Ishi
, Masato Yoshikawa
, Haruhi Kamisaki Ando
, William Farnaby
, Shinji Fujimoto
, Eiji Sunahara
, Momoko Ohori
, Matthew J. During
, Takanobu Kuroita
, Tatsuki Koike

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

119 Downloads (Pure)

1 results

2021
Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)
Koike, T. (Lead / Corresponding author), Yoshikawa, M., Ando, H. K., Farnaby, W., Nishi, T., Watanabe, E., Yano, J., Miyamoto, M., Kondo, S., Ishii, T. & Kuroita, T., 26 Aug 2021, In: Journal of Medicinal Chemistry. 64, 16, p. 12228-12244 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
44 Link opens in a new tab Citations (Scopus)

276 Downloads (Pure)