Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Toshiya Nishi, Shinichi Kondo, Maki Miyamoto, Sayuri Watanabe, Shigeo Hasegawa, Shigeru Kondo, Jason Yano, Etsurou Watanabe, Tsuyoshi Ishi, Masato Yoshikawa, Haruhi Kamisaki Ando, William Farnaby, Shinji Fujimoto, Eiji Sunahara, Momoko Ohori, Matthew J. During, Takanobu Kuroita, Tatsuki Koike

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

71 Downloads (Pure)

56 Citations
1 Article

1 results

2021
Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)
Koike, T. (Lead / Corresponding author), Yoshikawa, M., Ando, H. K., Farnaby, W., Nishi, T., Watanabe, E., Yano, J., Miyamoto, M., Kondo, S., Ishii, T. & Kuroita, T., 26 Aug 2021, In: Journal of Medicinal Chemistry. 64, 16, p. 12228-12244 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
33 Citations (Scopus)

152 Downloads (Pure)

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Research output

Search results

Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)