Spatial and temporal coordination of mitosis by Ran GTPase

Paul R. Clarke; Chuanmao Zhang

doi:10.1038/nrm2410

Spatial and temporal coordination of mitosis by Ran GTPase

Paul R. Clarke, Chuanmao Zhang

Research output: Contribution to journal › Review article › peer-review

344 Citations (Scopus)

Abstract

The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.

Original language	English
Pages (from-to)	464-477
Number of pages	14
Journal	Nature Reviews Molecular Cell Biology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1038/nrm2410
Publication status	Published - Jun 2008

Keywords

NUCLEAR-PORE COMPLEX
XENOPUS EGG EXTRACTS
MITOTIC SPINDLE FORMATION
PREMATURE CHROMOSOME CONDENSATION
GUANINE-NUCLEOTIDE EXCHANGE
CELL-CYCLE PROGRESSION
BINDING-PROTEIN RANBP1
AURORA-A ACTIVATION
RNA1 GENE-PRODUCT
IMPORTIN-BETA

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title = "Spatial and temporal coordination of mitosis by Ran GTPase",

abstract = "The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.",

keywords = "NUCLEAR-PORE COMPLEX, XENOPUS EGG EXTRACTS, MITOTIC SPINDLE FORMATION, PREMATURE CHROMOSOME CONDENSATION, GUANINE-NUCLEOTIDE EXCHANGE, CELL-CYCLE PROGRESSION, BINDING-PROTEIN RANBP1, AURORA-A ACTIVATION, RNA1 GENE-PRODUCT, IMPORTIN-BETA",

author = "Clarke, {Paul R.} and Chuanmao Zhang",

year = "2008",

month = jun,

doi = "10.1038/nrm2410",

language = "English",

volume = "9",

pages = "464--477",

journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

publisher = "Nature Research",

number = "6",

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TY - JOUR

T1 - Spatial and temporal coordination of mitosis by Ran GTPase

AU - Clarke, Paul R.

AU - Zhang, Chuanmao

PY - 2008/6

Y1 - 2008/6

N2 - The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.

AB - The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.

KW - NUCLEAR-PORE COMPLEX

KW - XENOPUS EGG EXTRACTS

KW - MITOTIC SPINDLE FORMATION

KW - PREMATURE CHROMOSOME CONDENSATION

KW - GUANINE-NUCLEOTIDE EXCHANGE

KW - CELL-CYCLE PROGRESSION

KW - BINDING-PROTEIN RANBP1

KW - AURORA-A ACTIVATION

KW - RNA1 GENE-PRODUCT

KW - IMPORTIN-BETA

U2 - 10.1038/nrm2410

DO - 10.1038/nrm2410

M3 - Review article

C2 - 18478030

SN - 1471-0072

VL - 9

SP - 464

EP - 477

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 6

ER -

Spatial and temporal coordination of mitosis by Ran GTPase

Abstract

Keywords

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