Spatial and temporal coordination of mitosis by Ran GTPase

Paul R. Clarke, Chuanmao Zhang

    Research output: Contribution to journalReview article

    275 Citations (Scopus)

    Abstract

    The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.

    Original languageEnglish
    Pages (from-to)464-477
    Number of pages14
    JournalNature Reviews Molecular Cell Biology
    Volume9
    Issue number6
    DOIs
    Publication statusPublished - Jun 2008

    Keywords

    • NUCLEAR-PORE COMPLEX
    • XENOPUS EGG EXTRACTS
    • MITOTIC SPINDLE FORMATION
    • PREMATURE CHROMOSOME CONDENSATION
    • GUANINE-NUCLEOTIDE EXCHANGE
    • CELL-CYCLE PROGRESSION
    • BINDING-PROTEIN RANBP1
    • AURORA-A ACTIVATION
    • RNA1 GENE-PRODUCT
    • IMPORTIN-BETA

    Cite this