Spatial regulation and organization of DNA replication within the nucleus

Toyoaki Natsume; Tomoyuki U. Tanaka

doi:10.1007/s10577-009-9088-0

Spatial regulation and organization of DNA replication within the nucleus

Toyoaki Natsume, Tomoyuki U. Tanaka

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans.

Original language	English
Pages (from-to)	7-17
Number of pages	11
Journal	Chromosome Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s10577-009-9088-0
Publication status	Published - Jan 2010

Keywords

DNA replication
replication origin
replication fork
replisome
replicon
replication focus
replication factory
XENOPUS EGG EXTRACTS
SACCHAROMYCES-CEREVISIAE
S-PHASE
CELL-CYCLE
CHROMOSOME-REPLICATION
YEAST TELOMERES
HIGH-RESOLUTION
BUDDING YEAST
FISSION YEAST
HISTONE DEACETYLASE

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title = "Spatial regulation and organization of DNA replication within the nucleus",

abstract = "Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans.",

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doi = "10.1007/s10577-009-9088-0",

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AU - Natsume, Toyoaki

AU - Tanaka, Tomoyuki U.

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AB - Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans.

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KW - replication origin

KW - replication fork

KW - replisome

KW - replicon

KW - replication focus

KW - replication factory

KW - XENOPUS EGG EXTRACTS

KW - SACCHAROMYCES-CEREVISIAE

KW - S-PHASE

KW - CELL-CYCLE

KW - CHROMOSOME-REPLICATION

KW - YEAST TELOMERES

KW - HIGH-RESOLUTION

KW - BUDDING YEAST

KW - FISSION YEAST

KW - HISTONE DEACETYLASE

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DO - 10.1007/s10577-009-9088-0

M3 - Article

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SN - 0967-3849

VL - 18

SP - 7

EP - 17

JO - Chromosome Research

JF - Chromosome Research

IS - 1

ER -

Spatial regulation and organization of DNA replication within the nucleus

Abstract

Keywords

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