Spatial resolution in dynamic optical coherence elastography

Mitchell A. Kirby, Kanheng Zhou, John J. Pitre, Liang Gao, David Li, Ivan Pelivanov (Lead / Corresponding author), Shaozhen Song, Chunhui Li, Zhihong Huang, Tueng Shen, Ruikang Wang, Matthew O'Donnell

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Abstract

Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundary's geometry and elasticity contrast, highly complex propagating fields produced near the boundary can substantially affect both the spatial resolution and contrast of the elasticity image. We demonstrate boundary effects on Rayleigh waves incident on a vertical boundary between media of different shear moduli. Lateral resolution is defined by the width of the transition zone between two media and is the limit at which a physical inclusion can be detected with full contrast. We experimentally demonstrate results using a spectral-domain OCT system on tissue-mimicking phantoms, which are replicated using numerical simulations. It is shown that the spatial resolution in dynamic OCE is determined by the temporal and spatial characteristics (i.e., bandwidth and spatial pulse width) of the propagating mechanical wave. Thus, mechanical resolution in dynamic OCE inherently differs from the optical resolution of the OCT imaging system.</p>.

Original languageEnglish
Article number096006
Number of pages16
JournalJournal of Biomedical Optics
Volume24
Issue number9
Early online date18 Sep 2019
DOIs
Publication statusPublished - Sep 2019

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Mechanical waves
spatial resolution
Elastic moduli
Elasticity
Tissue
modulus of elasticity
Rayleigh waves
elastic properties
Elastic waves
Imaging systems
Wave propagation
Acoustics
elastic waves
Bandwidth
Imaging techniques
wave propagation
Wavelength
near fields
pulse duration
Geometry

Keywords

  • contrast
  • dynamic elastography
  • group velocity
  • optical coherence elastography
  • optical coherence tomography
  • resolution
  • shear modulus
  • tissue elasticity

Cite this

Kirby, M. A., Zhou, K., Pitre, J. J., Gao, L., Li, D., Pelivanov, I., ... O'Donnell, M. (2019). Spatial resolution in dynamic optical coherence elastography. Journal of Biomedical Optics, 24(9), [096006]. https://doi.org/10.1117/1.JBO.24.9.096006
Kirby, Mitchell A. ; Zhou, Kanheng ; Pitre, John J. ; Gao, Liang ; Li, David ; Pelivanov, Ivan ; Song, Shaozhen ; Li, Chunhui ; Huang, Zhihong ; Shen, Tueng ; Wang, Ruikang ; O'Donnell, Matthew. / Spatial resolution in dynamic optical coherence elastography. In: Journal of Biomedical Optics. 2019 ; Vol. 24, No. 9.
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title = "Spatial resolution in dynamic optical coherence elastography",
abstract = "Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundary's geometry and elasticity contrast, highly complex propagating fields produced near the boundary can substantially affect both the spatial resolution and contrast of the elasticity image. We demonstrate boundary effects on Rayleigh waves incident on a vertical boundary between media of different shear moduli. Lateral resolution is defined by the width of the transition zone between two media and is the limit at which a physical inclusion can be detected with full contrast. We experimentally demonstrate results using a spectral-domain OCT system on tissue-mimicking phantoms, which are replicated using numerical simulations. It is shown that the spatial resolution in dynamic OCE is determined by the temporal and spatial characteristics (i.e., bandwidth and spatial pulse width) of the propagating mechanical wave. Thus, mechanical resolution in dynamic OCE inherently differs from the optical resolution of the OCT imaging system..",
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author = "Kirby, {Mitchell A.} and Kanheng Zhou and Pitre, {John J.} and Liang Gao and David Li and Ivan Pelivanov and Shaozhen Song and Chunhui Li and Zhihong Huang and Tueng Shen and Ruikang Wang and Matthew O'Donnell",
note = "This work was supported in part by NIH R01EY026532, R01EY024158, R01EB016034, R01CA170734, R01HL093140, Life Sciences Discovery Fund 3292512, the Coulter Translational Research Partnership Program, an unrestricted grant from the Research to Prevent Blindness, Inc., New York, New York, and the Department of Bioengineering at the University of Washington. This material was partially supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1256082.",
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Kirby, MA, Zhou, K, Pitre, JJ, Gao, L, Li, D, Pelivanov, I, Song, S, Li, C, Huang, Z, Shen, T, Wang, R & O'Donnell, M 2019, 'Spatial resolution in dynamic optical coherence elastography', Journal of Biomedical Optics, vol. 24, no. 9, 096006. https://doi.org/10.1117/1.JBO.24.9.096006

Spatial resolution in dynamic optical coherence elastography. / Kirby, Mitchell A.; Zhou, Kanheng; Pitre, John J.; Gao, Liang; Li, David; Pelivanov, Ivan (Lead / Corresponding author); Song, Shaozhen; Li, Chunhui; Huang, Zhihong; Shen, Tueng; Wang, Ruikang; O'Donnell, Matthew.

In: Journal of Biomedical Optics, Vol. 24, No. 9, 096006, 09.2019.

Research output: Contribution to journalArticle

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T1 - Spatial resolution in dynamic optical coherence elastography

AU - Kirby, Mitchell A.

AU - Zhou, Kanheng

AU - Pitre, John J.

AU - Gao, Liang

AU - Li, David

AU - Pelivanov, Ivan

AU - Song, Shaozhen

AU - Li, Chunhui

AU - Huang, Zhihong

AU - Shen, Tueng

AU - Wang, Ruikang

AU - O'Donnell, Matthew

N1 - This work was supported in part by NIH R01EY026532, R01EY024158, R01EB016034, R01CA170734, R01HL093140, Life Sciences Discovery Fund 3292512, the Coulter Translational Research Partnership Program, an unrestricted grant from the Research to Prevent Blindness, Inc., New York, New York, and the Department of Bioengineering at the University of Washington. This material was partially supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1256082.

PY - 2019/9

Y1 - 2019/9

N2 - Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundary's geometry and elasticity contrast, highly complex propagating fields produced near the boundary can substantially affect both the spatial resolution and contrast of the elasticity image. We demonstrate boundary effects on Rayleigh waves incident on a vertical boundary between media of different shear moduli. Lateral resolution is defined by the width of the transition zone between two media and is the limit at which a physical inclusion can be detected with full contrast. We experimentally demonstrate results using a spectral-domain OCT system on tissue-mimicking phantoms, which are replicated using numerical simulations. It is shown that the spatial resolution in dynamic OCE is determined by the temporal and spatial characteristics (i.e., bandwidth and spatial pulse width) of the propagating mechanical wave. Thus, mechanical resolution in dynamic OCE inherently differs from the optical resolution of the OCT imaging system..

AB - Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundary's geometry and elasticity contrast, highly complex propagating fields produced near the boundary can substantially affect both the spatial resolution and contrast of the elasticity image. We demonstrate boundary effects on Rayleigh waves incident on a vertical boundary between media of different shear moduli. Lateral resolution is defined by the width of the transition zone between two media and is the limit at which a physical inclusion can be detected with full contrast. We experimentally demonstrate results using a spectral-domain OCT system on tissue-mimicking phantoms, which are replicated using numerical simulations. It is shown that the spatial resolution in dynamic OCE is determined by the temporal and spatial characteristics (i.e., bandwidth and spatial pulse width) of the propagating mechanical wave. Thus, mechanical resolution in dynamic OCE inherently differs from the optical resolution of the OCT imaging system..

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KW - dynamic elastography

KW - group velocity

KW - optical coherence elastography

KW - optical coherence tomography

KW - resolution

KW - shear modulus

KW - tissue elasticity

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