Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation

Marc Sturrock, Andreas Hellander, Anastasios Matzavinos, Mark A J Chaplain

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment.
Original languageEnglish
Pages (from-to)20120988
JournalJournal of the Royal Society Interface
Volume10
Issue number80
DOIs
Publication statusPublished - 2013

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