TY - JOUR
T1 - Spatial stochastic modelling of the Hes1 gene regulatory network
T2 - intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
AU - Sturrock, Marc
AU - Hellander, Andreas
AU - Matzavinos, Anastasios
AU - Chaplain, Mark A J
PY - 2013
Y1 - 2013
N2 - Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment.
AB - Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment.
U2 - 10.1098/rsif.2012.0988
DO - 10.1098/rsif.2012.0988
M3 - Article
C2 - 23325756
SN - 1742-5662
VL - 10
SP - 20120988
JO - Journal of the Royal Society. Interface
JF - Journal of the Royal Society. Interface
IS - 80
ER -