Specificity and disease in the ubiquitin system

Viduth K. Chaugule; Helen Walden

doi:10.1042/BST20150209

Specificity and disease in the ubiquitin system

Viduth K. Chaugule
, Helen Walden (Lead / Corresponding author)

MRC PPU

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

284 Downloads (Pure)

Abstract

Post-translational modification (PTM) of proteins by ubiquitination is an essential cellular regulatory process. Such regulation drives the cell cycle and cell division, signalling and secretory pathways, DNA replication and repair processes and protein quality control and degradation pathways. A huge range of ubiquitin signals can be generated depending on the specificity and catalytic activity of the enzymes required for attachment of ubiquitin to a given target. As a consequence of its importance to eukaryotic life, dysfunction in the ubiquitin system leads to many disease states, including cancers and neurodegeneration. This review takes a retrospective look at our progress in understanding the molecular mechanisms that govern the specificity of ubiquitin conjugation.

Original language	English
Pages (from-to)	212-227
Number of pages	16
Journal	Biochemical Society Transactions
Volume	44
Issue number	1
Early online date	9 Feb 2016
DOIs	https://doi.org/10.1042/BST20150209
Publication status	Published - 15 Feb 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ubiquitin
E3 ligase
RING
RBR
Fanconi anemia
parkin

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10.1042/BST20150209Licence: CC BY

Final Published Version
Copyright 2016 Authors. This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0.
Final published version, 954 KBLicence: CC BY

Cite this

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AB - Post-translational modification (PTM) of proteins by ubiquitination is an essential cellular regulatory process. Such regulation drives the cell cycle and cell division, signalling and secretory pathways, DNA replication and repair processes and protein quality control and degradation pathways. A huge range of ubiquitin signals can be generated depending on the specificity and catalytic activity of the enzymes required for attachment of ubiquitin to a given target. As a consequence of its importance to eukaryotic life, dysfunction in the ubiquitin system leads to many disease states, including cancers and neurodegeneration. This review takes a retrospective look at our progress in understanding the molecular mechanisms that govern the specificity of ubiquitin conjugation.

KW - ubiquitin

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KW - RING

KW - RBR

KW - Fanconi anemia

KW - parkin

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Specificity and disease in the ubiquitin system

Abstract

UN SDGs

Keywords

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