Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe; Vincenzo A. Rao; Aleksandra Zemla; Scott Cameron; William N. Hunter

doi:10.1002/anie.200903407

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe, Vincenzo A. Rao, Aleksandra Zemla, Scott Cameron, William N. Hunter (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	9176-9179
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	48
Issue number	48
DOIs	https://doi.org/10.1002/anie.200903407
Publication status	Published - 2009

Keywords

drug discovery
enzymes
mechanisms
tuberculosis
zinc
MYCOBACTERIUM-TUBERCULOSIS
CRYSTAL-STRUCTURE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/anie.200903407

Cite this

@article{0ee6ee4e6fef4c4883cc2605e6e5f5ab,

title = "Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide",

keywords = "drug discovery, enzymes, mechanisms, tuberculosis, zinc, MYCOBACTERIUM-TUBERCULOSIS, CRYSTAL-STRUCTURE",

author = "Fyfe, {Paul K.} and Rao, {Vincenzo A.} and Aleksandra Zemla and Scott Cameron and Hunter, {William N.}",

year = "2009",

doi = "10.1002/anie.200903407",

language = "English",

volume = "48",

pages = "9176--9179",

journal = "Angewandte Chemie International Edition",

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}

TY - JOUR

T1 - Specificity and mechanism of Acinetobacter baumanii nicotinamidase

T2 - implications for activation of the front-line tuberculosis drug pyrazinamide

AU - Fyfe, Paul K.

AU - Rao, Vincenzo A.

AU - Zemla, Aleksandra

AU - Cameron, Scott

AU - Hunter, William N.

PY - 2009

Y1 - 2009

KW - drug discovery

KW - enzymes

KW - mechanisms

KW - tuberculosis

KW - zinc

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - CRYSTAL-STRUCTURE

UR - http://www.scopus.com/inward/record.url?scp=70449562067&partnerID=8YFLogxK

U2 - 10.1002/anie.200903407

DO - 10.1002/anie.200903407

M3 - Article

SN - 1433-7851

VL - 48

SP - 9176

EP - 9179

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 48

ER -

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Keywords

UN SDGs

Access to Document

Other files and links

Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

Cite this

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

Cite this