Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe; Vincenzo A. Rao; Aleksandra Zemla; Scott Cameron; William N. Hunter

doi:10.1002/anie.200903407

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe, Vincenzo A. Rao, Aleksandra Zemla, Scott Cameron, William N. Hunter (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	9176-9179
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	48
Issue number	48
DOIs	https://doi.org/10.1002/anie.200903407
Publication status	Published - 2009

Keywords

drug discovery
enzymes
mechanisms
tuberculosis
zinc
MYCOBACTERIUM-TUBERCULOSIS
CRYSTAL-STRUCTURE

Access to Document

10.1002/anie.200903407

Link to publication in Scopus

2 Finished

Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)
Fairlamb, A., Ferguson, M. & Frearson, J.
Wellcome Trust
1/01/08 → 31/12/12
Project: Research
Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)
Hunter, B.
Wellcome Trust
1/11/07 → 31/12/13
Project: Research

Cite this

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title = "Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide",

keywords = "drug discovery, enzymes, mechanisms, tuberculosis, zinc, MYCOBACTERIUM-TUBERCULOSIS, CRYSTAL-STRUCTURE",

author = "Fyfe, {Paul K.} and Rao, {Vincenzo A.} and Aleksandra Zemla and Scott Cameron and Hunter, {William N.}",

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Specificity and mechanism of Acinetobacter baumanii nicotinamidase : implications for activation of the front-line tuberculosis drug pyrazinamide. / Fyfe, Paul K.; Rao, Vincenzo A.; Zemla, Aleksandra; Cameron, Scott; Hunter, William N. (Lead / Corresponding author).

In: Angewandte Chemie International Edition, Vol. 48, No. 48, 2009, p. 9176-9179.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Specificity and mechanism of Acinetobacter baumanii nicotinamidase

T2 - implications for activation of the front-line tuberculosis drug pyrazinamide

AU - Fyfe, Paul K.

AU - Rao, Vincenzo A.

AU - Zemla, Aleksandra

AU - Cameron, Scott

AU - Hunter, William N.

PY - 2009

Y1 - 2009

KW - drug discovery

KW - enzymes

KW - mechanisms

KW - tuberculosis

KW - zinc

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - CRYSTAL-STRUCTURE

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U2 - 10.1002/anie.200903407

DO - 10.1002/anie.200903407

M3 - Article

VL - 48

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EP - 9179

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 48

ER -

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Keywords

Access to Document

Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

Cite this