TY - JOUR
T1 - Spectral power ratio as a measure of EEG changes in mild cognitive impairment due to Alzheimer's disease
T2 - a case-control study
AU - Flores-Sandoval, Aimee A.
AU - Davila-Pérez, Paula
AU - Buss, Stephanie S.
AU - Donohoe, Kevin
AU - O'Connor, Margaret
AU - Shafi, Mouhsin M.
AU - Pascual-Leone, Alvaro
AU - Benwell, Christopher S. Y.
AU - Fried, Peter J.
N1 - Copyright:
© 2023 Elsevier Inc. All rights reserved.
PY - 2023/10
Y1 - 2023/10
N2 - Adopting preventive strategies in individuals with subclinical Alzheimer's disease (AD) has the potential to delay dementia onset and reduce healthcare costs. Thus, it is extremely important to identify inexpensive, scalable, sensitive, and specific markers to track disease progression. The electroencephalography spectral power ratio (SPR: the fast to slow spectral power ratio), a measure of the shift in power distribution from higher to lower frequencies, holds potential for aiding clinical practice. The SPR is altered in patients with AD, correlates with cognitive functions, and can be easily implemented in clinical settings. However, whether the SPR is sensitive to pathophysiological changes in the prodromal stage of AD is unclear. We explored the SPR of individuals diagnosed with amyloid-positive amnestic mild cognitive impairment (Aβ+aMCI) and its association with both cognitive function and amyloid load. The SPR was lower in Aβ+aMCI than in the cognitively unimpaired individuals and correlated with executive function scores but not with amyloid load. Hypothesis-generating analyses suggested that aMCI participants with a lower SPR had an increased probability of a positive amyloid positron emission tomography. Future research may explore the potential of this measure to classify aMCI individuals according to their AD biomarker status.
AB - Adopting preventive strategies in individuals with subclinical Alzheimer's disease (AD) has the potential to delay dementia onset and reduce healthcare costs. Thus, it is extremely important to identify inexpensive, scalable, sensitive, and specific markers to track disease progression. The electroencephalography spectral power ratio (SPR: the fast to slow spectral power ratio), a measure of the shift in power distribution from higher to lower frequencies, holds potential for aiding clinical practice. The SPR is altered in patients with AD, correlates with cognitive functions, and can be easily implemented in clinical settings. However, whether the SPR is sensitive to pathophysiological changes in the prodromal stage of AD is unclear. We explored the SPR of individuals diagnosed with amyloid-positive amnestic mild cognitive impairment (Aβ+aMCI) and its association with both cognitive function and amyloid load. The SPR was lower in Aβ+aMCI than in the cognitively unimpaired individuals and correlated with executive function scores but not with amyloid load. Hypothesis-generating analyses suggested that aMCI participants with a lower SPR had an increased probability of a positive amyloid positron emission tomography. Future research may explore the potential of this measure to classify aMCI individuals according to their AD biomarker status.
KW - Mild cognitive impairment
KW - Spectral power ratio
KW - Amyloid
KW - EEG
KW - Neurophysiology
UR - http://www.scopus.com/inward/record.url?scp=85165988559&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2023.05.010
DO - 10.1016/j.neurobiolaging.2023.05.010
M3 - Article
C2 - 37459658
SN - 0197-4580
VL - 130
SP - 50
EP - 60
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -