Sperm cryopreservation for impaired spermatogenesis

George Hughes, Sarah Martins da Silva (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
66 Downloads (Pure)


Sperm cryopreservation for men with severely impaired spermatogenesis is one of the commonest reasons for short-term sperm storage, usually in advance of fertility treatment. Cryopreservation is generally very effective, although not all spermatozoa survive the process of freezing and thawing. This review considers various aspects of freezing sperm, including an overview of methods, appropriate use of cryoprotectants and practical considerations, as well as oxidative stress and mechanisms of cell cryodamage.

Original languageEnglish
Article numbere220106
Number of pages11
JournalReproduction & Fertility
Issue number1
Early online date18 Jan 2023
Publication statusPublished - Jan 2023


  • ICSI
  • cryostorage
  • male infertility
  • sperm
  • spermatogenesis

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Embryology
  • Reproductive Medicine


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