Spinal anaesthesia for Caesarean section with bupivacaine 5 mg ml–1 in glucose 8 or 80 mg ml–1

C. Connolly, G. A. McLeod, J. A. W. Wildsmith

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The standard spinal preparation of bupivacaine contains a high concentration of glucose (80 mg ml). However, the addition of only a small amount of glucose (8 mg ml) to plain solutions of bupivacaine results in a solution which, although no more than marginally hyperbaric, produces a more predictable block when used for spinal anaesthesia in non-pregnant patients. However, bupivacaine 5 mg ml in glucose 8 mg ml has a density [1.00164 (SD 0.00008) at 37°C] which is relatively greater than that of the cerebrospinal fluid (CSF) of the pregnant patient at term (1.0003 at 37°C) because CSF density decreases during pregnancy. Therefore, a double-blind, randomized, controlled study was carried out to compare intrathecal bupivacaine (glucose 8 mg ml) with bupivacaine (glucose 80 mg ml) in 40 pregnant patients at term. Although there was no difference between groups in onset of sensory block, dose of ephedrine or patient satisfaction, patients receiving bupivacaine (5 mg ml) with glucose (8 mg ml) had persistently higher sensory blocks between 60 and 120 min after intrathecal injection, suggesting that the spread of spinal solutions in the pregnant patient at term is not dependent on density.
    Original languageEnglish
    Pages (from-to)805-807
    Number of pages3
    JournalBritish Journal of Anaesthesia
    Volume86
    Issue number6
    DOIs
    Publication statusPublished - Jun 2001

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    Spinal Anesthesia
    Bupivacaine
    Cesarean Section
    Glucose
    Cerebrospinal Fluid
    Ephedrine
    Spinal Injections
    Patient Satisfaction
    Pregnancy

    Cite this

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    abstract = "The standard spinal preparation of bupivacaine contains a high concentration of glucose (80 mg ml). However, the addition of only a small amount of glucose (8 mg ml) to plain solutions of bupivacaine results in a solution which, although no more than marginally hyperbaric, produces a more predictable block when used for spinal anaesthesia in non-pregnant patients. However, bupivacaine 5 mg ml in glucose 8 mg ml has a density [1.00164 (SD 0.00008) at 37°C] which is relatively greater than that of the cerebrospinal fluid (CSF) of the pregnant patient at term (1.0003 at 37°C) because CSF density decreases during pregnancy. Therefore, a double-blind, randomized, controlled study was carried out to compare intrathecal bupivacaine (glucose 8 mg ml) with bupivacaine (glucose 80 mg ml) in 40 pregnant patients at term. Although there was no difference between groups in onset of sensory block, dose of ephedrine or patient satisfaction, patients receiving bupivacaine (5 mg ml) with glucose (8 mg ml) had persistently higher sensory blocks between 60 and 120 min after intrathecal injection, suggesting that the spread of spinal solutions in the pregnant patient at term is not dependent on density.",
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    Spinal anaesthesia for Caesarean section with bupivacaine 5 mg ml–1 in glucose 8 or 80 mg ml–1. / Connolly, C.; McLeod, G. A.; Wildsmith, J. A. W.

    In: British Journal of Anaesthesia, Vol. 86, No. 6, 06.2001, p. 805-807.

    Research output: Contribution to journalArticle

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