Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle

Mayra Petasny, Mercedes Bentata, Andrea Pawellek, Mai Baker, Gillian Kay, Maayan Salton (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)
    293 Downloads (Pure)

    Abstract

    Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle.

    Original languageEnglish
    Pages (from-to)266-278
    Number of pages13
    JournalTrends in Genetics
    Volume37
    Issue number3
    Early online date16 Sept 2020
    DOIs
    Publication statusPublished - Mar 2021

    Keywords

    • pre-mRNA splicing
    • cell cycle
    • alternative splicing
    • splicing factors
    • splicing
    • splicing regulation

    ASJC Scopus subject areas

    • Genetics

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