Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

Caroline E. Whitworth; Stewart Fleming; Allan D. Cumming; James J. Morton; Nicola J. T. Burns; Brent C. Williams; John J. Mullins

doi:doi:10.1038/ki.1994.437

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

Caroline E. Whitworth, Stewart Fleming, Allan D. Cumming, James J. Morton, Nicola J. T. Burns, Brent C. Williams, John J. Mullins

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Abstract

Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.

Original language	English
Pages (from-to)	1528-32
Number of pages	5
Journal	Kidney International
Volume	46
Issue number	6
DOIs	https://doi.org/doi:10.1038/ki.1994.437
Publication status	Published - 1994

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doi:10.1038/ki.1994.437

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title = "Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats",

abstract = "Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.",

author = "Whitworth, {Caroline E.} and Stewart Fleming and Cumming, {Allan D.} and Morton, {James J.} and Burns, {Nicola J. T.} and Williams, {Brent C.} and Mullins, {John J.}",

year = "1994",

doi = "doi:10.1038/ki.1994.437",

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journal = "Kidney International",

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T1 - Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

AU - Whitworth, Caroline E.

AU - Fleming, Stewart

AU - Cumming, Allan D.

AU - Morton, James J.

AU - Burns, Nicola J. T.

AU - Williams, Brent C.

AU - Mullins, John J.

PY - 1994

Y1 - 1994

N2 - Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.

AB - Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.

U2 - doi:10.1038/ki.1994.437

DO - doi:10.1038/ki.1994.437

M3 - Article

C2 - 7699997

SN - 0085-2538

VL - 46

SP - 1528

EP - 1532

JO - Kidney International

JF - Kidney International

IS - 6

ER -

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

Abstract

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