Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

Caroline E. Whitworth, Stewart Fleming, Allan D. Cumming, James J. Morton, Nicola J. T. Burns, Brent C. Williams, John J. Mullins

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    34 Citations (Scopus)

    Abstract

    Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
    Original languageEnglish
    Pages (from-to)1528-32
    Number of pages5
    JournalKidney International
    Volume46
    Issue number6
    DOIs
    Publication statusPublished - 1994

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