Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

TY - JOUR

T1 - Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

AU - Whitworth, Caroline E.

AU - Fleming, Stewart

AU - Cumming, Allan D.

AU - Morton, James J.

AU - Burns, Nicola J. T.

AU - Williams, Brent C.

AU - Mullins, John J.

PY - 1994

Y1 - 1994

N2 - Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.

AB - Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.

U2 - doi:10.1038/ki.1994.437

DO - doi:10.1038/ki.1994.437

M3 - Article

C2 - 7699997

SN - 0085-2538

VL - 46

SP - 1528

EP - 1532

JO - Kidney International

JF - Kidney International

IS - 6

ER -