Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse PSM

Shinichi Hayashi, Taiju Shimoda, Masato Nakajima, Yuki Tsukada, Yuichi Sakumura, J. Kim Dale, Miguel Maroto, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Background: During vertebrate embryogenesis, somites are generated at regular intervals, the temporal and spatial periodicity of which is governed by a gradient of fibroblast growth factor (FGF) and/or Wnt signaling activity in the presomitic mesoderm (PSM) in conjunction with oscillations of gene expression of components of the Notch, Wnt and FGF signaling pathways.

    Principal Findings: Here, we show that the expression of Sprouty4, which encodes an FGF inhibitor, oscillates in 2-h cycles in the mouse PSM in synchrony with other oscillating genes from the Notch signaling pathway, such as lunatic fringe. Sprouty4 does not oscillate in Hes7-null mutant mouse embryos, and Hes7 can inhibit FGF-induced transcriptional activity of the Sprouty4 promoter.

    Conclusions: Thus, periodic expression of Sprouty4 is controlled by the Notch segmentation clock and may work as a mediator that links the temporal periodicity of clock gene oscillations with the spatial periodicity of boundary formation which is regulated by the gradient of FGF/Wnt activity.

    Original languageEnglish
    Article numbere5603
    Pages (from-to)-
    Number of pages8
    JournalPLoS ONE
    Volume4
    Issue number5
    DOIs
    Publication statusPublished - 19 May 2009

    Cite this

    Hayashi, Shinichi ; Shimoda, Taiju ; Nakajima, Masato ; Tsukada, Yuki ; Sakumura, Yuichi ; Dale, J. Kim ; Maroto, Miguel ; Kohno, Kenji ; Matsui, Takaaki ; Bessho, Yasumasa. / Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse PSM. In: PLoS ONE. 2009 ; Vol. 4, No. 5. pp. -.
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    title = "Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse PSM",
    abstract = "Background: During vertebrate embryogenesis, somites are generated at regular intervals, the temporal and spatial periodicity of which is governed by a gradient of fibroblast growth factor (FGF) and/or Wnt signaling activity in the presomitic mesoderm (PSM) in conjunction with oscillations of gene expression of components of the Notch, Wnt and FGF signaling pathways.Principal Findings: Here, we show that the expression of Sprouty4, which encodes an FGF inhibitor, oscillates in 2-h cycles in the mouse PSM in synchrony with other oscillating genes from the Notch signaling pathway, such as lunatic fringe. Sprouty4 does not oscillate in Hes7-null mutant mouse embryos, and Hes7 can inhibit FGF-induced transcriptional activity of the Sprouty4 promoter.Conclusions: Thus, periodic expression of Sprouty4 is controlled by the Notch segmentation clock and may work as a mediator that links the temporal periodicity of clock gene oscillations with the spatial periodicity of boundary formation which is regulated by the gradient of FGF/Wnt activity.",
    author = "Shinichi Hayashi and Taiju Shimoda and Masato Nakajima and Yuki Tsukada and Yuichi Sakumura and Dale, {J. Kim} and Miguel Maroto and Kenji Kohno and Takaaki Matsui and Yasumasa Bessho",
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    Hayashi, S, Shimoda, T, Nakajima, M, Tsukada, Y, Sakumura, Y, Dale, JK, Maroto, M, Kohno, K, Matsui, T & Bessho, Y 2009, 'Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse PSM', PLoS ONE, vol. 4, no. 5, e5603, pp. -. https://doi.org/10.1371/journal.pone.0005603

    Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse PSM. / Hayashi, Shinichi; Shimoda, Taiju; Nakajima, Masato; Tsukada, Yuki; Sakumura, Yuichi; Dale, J. Kim; Maroto, Miguel; Kohno, Kenji; Matsui, Takaaki; Bessho, Yasumasa.

    In: PLoS ONE, Vol. 4, No. 5, e5603, 19.05.2009, p. -.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse PSM

    AU - Hayashi, Shinichi

    AU - Shimoda, Taiju

    AU - Nakajima, Masato

    AU - Tsukada, Yuki

    AU - Sakumura, Yuichi

    AU - Dale, J. Kim

    AU - Maroto, Miguel

    AU - Kohno, Kenji

    AU - Matsui, Takaaki

    AU - Bessho, Yasumasa

    PY - 2009/5/19

    Y1 - 2009/5/19

    N2 - Background: During vertebrate embryogenesis, somites are generated at regular intervals, the temporal and spatial periodicity of which is governed by a gradient of fibroblast growth factor (FGF) and/or Wnt signaling activity in the presomitic mesoderm (PSM) in conjunction with oscillations of gene expression of components of the Notch, Wnt and FGF signaling pathways.Principal Findings: Here, we show that the expression of Sprouty4, which encodes an FGF inhibitor, oscillates in 2-h cycles in the mouse PSM in synchrony with other oscillating genes from the Notch signaling pathway, such as lunatic fringe. Sprouty4 does not oscillate in Hes7-null mutant mouse embryos, and Hes7 can inhibit FGF-induced transcriptional activity of the Sprouty4 promoter.Conclusions: Thus, periodic expression of Sprouty4 is controlled by the Notch segmentation clock and may work as a mediator that links the temporal periodicity of clock gene oscillations with the spatial periodicity of boundary formation which is regulated by the gradient of FGF/Wnt activity.

    AB - Background: During vertebrate embryogenesis, somites are generated at regular intervals, the temporal and spatial periodicity of which is governed by a gradient of fibroblast growth factor (FGF) and/or Wnt signaling activity in the presomitic mesoderm (PSM) in conjunction with oscillations of gene expression of components of the Notch, Wnt and FGF signaling pathways.Principal Findings: Here, we show that the expression of Sprouty4, which encodes an FGF inhibitor, oscillates in 2-h cycles in the mouse PSM in synchrony with other oscillating genes from the Notch signaling pathway, such as lunatic fringe. Sprouty4 does not oscillate in Hes7-null mutant mouse embryos, and Hes7 can inhibit FGF-induced transcriptional activity of the Sprouty4 promoter.Conclusions: Thus, periodic expression of Sprouty4 is controlled by the Notch segmentation clock and may work as a mediator that links the temporal periodicity of clock gene oscillations with the spatial periodicity of boundary formation which is regulated by the gradient of FGF/Wnt activity.

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