Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment

Guilherme Vieira de Castro; Alessio Ciulli

doi:10.1039/C8CC09790A

Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment

Guilherme Vieira de Castro, Alessio Ciulli (Lead / Corresponding author)

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article

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Abstract

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive ¹⁹F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

Original language	English
Pages (from-to)	1482-1485
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	10
Early online date	15 Jan 2019
DOIs	https://doi.org/10.1039/C8CC09790A
Publication status	Published - 4 Feb 2019

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Assays

Screening

Ligands

Nuclear magnetic resonance

Molecules

Experiments

Cite this

Castro, G. V. D., & Ciulli, A. (2019). Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment. Chemical Communications, 55(10), 1482-1485. https://doi.org/10.1039/C8CC09790A

Castro, Guilherme Vieira de ; Ciulli, Alessio. / Spy vs. Spy : Selecting the best reporter for 19F NMR competition experiment. In: Chemical Communications. 2019 ; Vol. 55, No. 10. pp. 1482-1485.

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Castro, GVD & Ciulli, A 2019, 'Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment' Chemical Communications, vol. 55, no. 10, pp. 1482-1485. https://doi.org/10.1039/C8CC09790A

Spy vs. Spy : Selecting the best reporter for 19F NMR competition experiment. / Castro, Guilherme Vieira de ; Ciulli, Alessio (Lead / Corresponding author).

In: Chemical Communications, Vol. 55, No. 10, 04.02.2019, p. 1482-1485.

Research output: Contribution to journal › Article

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