Abstract
Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.
Original language | English |
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Pages (from-to) | 1482-1485 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 55 |
Issue number | 10 |
Early online date | 15 Jan 2019 |
DOIs | |
Publication status | Published - 4 Feb 2019 |
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Dive into the research topics of 'Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment'. Together they form a unique fingerprint.Student Theses
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Fragment-based approaches to probe the surface of the VHL E3 ligase
Author: Castro, G., 2019Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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