Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment

Guilherme Vieira de Castro, Alessio Ciulli (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
79 Downloads (Pure)

Abstract

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

Original languageEnglish
Pages (from-to)1482-1485
Number of pages4
JournalChemical Communications
Volume55
Issue number10
Early online date15 Jan 2019
DOIs
Publication statusPublished - 4 Feb 2019

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