Abstract
Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.
| Original language | English |
|---|---|
| Pages (from-to) | 1482-1485 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 10 |
| Early online date | 15 Jan 2019 |
| DOIs | |
| Publication status | Published - 4 Feb 2019 |
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Spy vs. Spy : Selecting the best reporter for 19F NMR competition experiment. / Castro, Guilherme Vieira de; Ciulli, Alessio (Lead / Corresponding author).
In: Chemical Communications, Vol. 55, No. 10, 04.02.2019, p. 1482-1485.Research output: Contribution to journal › Article
TY - JOUR
T1 - Spy vs. Spy
T2 - Selecting the best reporter for 19F NMR competition experiment
AU - Castro, Guilherme Vieira de
AU - Ciulli, Alessio
N1 - This project has received funding from the European Research Council (ERC) under the European Union’s Seventh Frame- work Programme (FP7/2007−2013) as a Starting Grant to A.C. (grant agreement no. ERC-2012-StG-311460 DrugE3CRLs) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Ph.D. Studentship 7148-14-3 to G.V.C.). Biophysics and drug discovery activities were supported by Wellcome Trust strategic awards to Dundee (100476/Z/12/Z and 094090/Z/10/Z, respectively).
PY - 2019/2/4
Y1 - 2019/2/4
N2 - Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.
AB - Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.
UR - http://www.scopus.com/inward/record.url?scp=85060636080&partnerID=8YFLogxK
U2 - 10.1039/C8CC09790A
DO - 10.1039/C8CC09790A
M3 - Article
VL - 55
SP - 1482
EP - 1485
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 10
ER -