TY - JOUR
T1 - Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds
AU - Khabnadideh, Soghra
AU - Tan, Choon Leei
AU - Croft, Simon L.
AU - Kendrick, Howard
AU - Yardley, Vanessa
AU - Gilbert, Ian H.
PY - 2000
Y1 - 2000
N2 - This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent, squalamine. The compounds were then investigated for activity against Trypanosoma brucei, the causative agent of African trypanosomiasis, Trypanosoma cruzi, the causative agent of Chagas disease and Leishmania donovani, the causative agent of visceral leishmaniasis. Several compounds showed in vitro activity, especially against T. brucei and L. donovani. However, one compound showed poor in vivo activity, (C) 2000 Elsevier Science Ltd. All rights reserved.
AB - This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent, squalamine. The compounds were then investigated for activity against Trypanosoma brucei, the causative agent of African trypanosomiasis, Trypanosoma cruzi, the causative agent of Chagas disease and Leishmania donovani, the causative agent of visceral leishmaniasis. Several compounds showed in vitro activity, especially against T. brucei and L. donovani. However, one compound showed poor in vivo activity, (C) 2000 Elsevier Science Ltd. All rights reserved.
U2 - 10.1016/S0960-894X(00)00196-7
DO - 10.1016/S0960-894X(00)00196-7
M3 - Article
SN - 0960-894X
VL - 10
SP - 1237
EP - 1239
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 11
ER -