Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds

Soghra Khabnadideh, Choon Leei Tan, Simon L. Croft, Howard Kendrick, Vanessa Yardley, Ian H. Gilbert

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    28 Citations (Scopus)

    Abstract

    This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent, squalamine. The compounds were then investigated for activity against Trypanosoma brucei, the causative agent of African trypanosomiasis, Trypanosoma cruzi, the causative agent of Chagas disease and Leishmania donovani, the causative agent of visceral leishmaniasis. Several compounds showed in vitro activity, especially against T. brucei and L. donovani. However, one compound showed poor in vivo activity, (C) 2000 Elsevier Science Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)1237-1239
    Number of pages3
    JournalBioorganic & Medicinal Chemistry Letters
    Volume10
    Issue number11
    DOIs
    Publication statusPublished - 2000

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