Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds

TY - JOUR

T1 - Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds

AU - Khabnadideh, Soghra

AU - Tan, Choon Leei

AU - Croft, Simon L.

AU - Kendrick, Howard

AU - Yardley, Vanessa

AU - Gilbert, Ian H.

PY - 2000

Y1 - 2000

N2 - This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent, squalamine. The compounds were then investigated for activity against Trypanosoma brucei, the causative agent of African trypanosomiasis, Trypanosoma cruzi, the causative agent of Chagas disease and Leishmania donovani, the causative agent of visceral leishmaniasis. Several compounds showed in vitro activity, especially against T. brucei and L. donovani. However, one compound showed poor in vivo activity, (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent, squalamine. The compounds were then investigated for activity against Trypanosoma brucei, the causative agent of African trypanosomiasis, Trypanosoma cruzi, the causative agent of Chagas disease and Leishmania donovani, the causative agent of visceral leishmaniasis. Several compounds showed in vitro activity, especially against T. brucei and L. donovani. However, one compound showed poor in vivo activity, (C) 2000 Elsevier Science Ltd. All rights reserved.

U2 - 10.1016/S0960-894X(00)00196-7

DO - 10.1016/S0960-894X(00)00196-7

M3 - Article

SN - 0960-894X

VL - 10

SP - 1237

EP - 1239

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 11

ER -