State of the art review: management of bronchiectasis in adults

James D. Chalmers, Stefano Aliberti, Francesco Blasi (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    129 Citations (Scopus)

    Abstract

    Formerly regarded as a rare disease, bronchiectasis is now increasingly recognised and a renewed interest in the condition is stimulating drug development and clinical research. Bronchiectasis represents the final common pathway of a number of infectious, genetic, autoimmune, developmental and allergic disorders and is highly heterogeneous in its aetiology, impact and prognosis. The goals of therapy should be: to improve airway mucus clearance through physiotherapy with or without adjunctive therapies; to suppress, eradicate and prevent airway bacterial colonisation; to reduce airway inflammation; and to improve physical functioning and quality of life. Fortunately, an increasing body of evidence supports interventions in bronchiectasis. The field has benefited greatly from the introduction of evidence-based guidelines in some European countries and randomised controlled trials have now demonstrated the benefit of long-term macrolide therapy, with accumulating evidence for inhaled therapies, physiotherapy and pulmonary rehabilitation. This review provides a critical update on the management of bronchiectasis focussing on emerging evidence and recent randomised controlled trials.

    Original languageEnglish
    Pages (from-to)1446-1462
    Number of pages12
    JournalEuropean Respiratory Journal
    Volume45
    Issue number5
    Early online date18 Mar 2015
    DOIs
    Publication statusPublished - 1 May 2015

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