Statin use and association with colorectal cancer survival and risk: Case control study with prescription data linkage

Fatim Lakha; Evropi Theodoratou; Susan M. Farrington; Albert Tenesa; Roseanne Cetnarskyj; Farhat V. N. Din; Mary E. Porteous; Malcolm G. Dunlop; Harry Campbell

doi:10.1186/1471-2407-12-487

Statin use and association with colorectal cancer survival and risk: Case control study with prescription data linkage

Fatim Lakha (Lead / Corresponding author), Evropi Theodoratou, Susan M. Farrington, Albert Tenesa, Roseanne Cetnarskyj, Farhat V. N. Din, Mary E. Porteous, Malcolm G. Dunlop, Harry Campbell

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Abstract

Background: In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival.

Methods: Analysis was carried out on 309 cases and 294 controls from the Scottish Study of Colorectal Cancer (SOCCS). Cox's hazard and logistic regression models were applied to investigate the association between statin use and CRC risk and survival.

Results: In an adjusted logistic regression model, statins were found to show a statistically significant association for three of the four statin variables and were found to not show a statistically significant association with either all-cause or CRC-specific mortality (OR 0.49; 95%CI 0.49-1.36; p-value = 0.17 and OR 0.33; 95%CI 0.08-1.35; P-value = 0.12, respectively).

Conclusion: We did find a statistically significant association between statin intake and CRC risk but not statin intake and CRC-specific mortality. However, the study was insufficiently powered and larger scale studies may be advisable.

Original language	English
Article number	487
Pages (from-to)	1-10
Number of pages	10
Journal	BMC Cancer
Volume	12
DOIs	https://doi.org/10.1186/1471-2407-12-487
Publication status	Published - 22 Oct 2012

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Statin use and association with colorectal cancer survival and risk: Case control study with prescription data linkage",

abstract = "Background: In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival.Methods: Analysis was carried out on 309 cases and 294 controls from the Scottish Study of Colorectal Cancer (SOCCS). Cox's hazard and logistic regression models were applied to investigate the association between statin use and CRC risk and survival.Results: In an adjusted logistic regression model, statins were found to show a statistically significant association for three of the four statin variables and were found to not show a statistically significant association with either all-cause or CRC-specific mortality (OR 0.49; 95%CI 0.49-1.36; p-value = 0.17 and OR 0.33; 95%CI 0.08-1.35; P-value = 0.12, respectively).Conclusion: We did find a statistically significant association between statin intake and CRC risk but not statin intake and CRC-specific mortality. However, the study was insufficiently powered and larger scale studies may be advisable.",

author = "Fatim Lakha and Evropi Theodoratou and Farrington, {Susan M.} and Albert Tenesa and Roseanne Cetnarskyj and Din, {Farhat V. N.} and Porteous, {Mary E.} and Dunlop, {Malcolm G.} and Harry Campbell",

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doi = "10.1186/1471-2407-12-487",

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T1 - Statin use and association with colorectal cancer survival and risk

T2 - Case control study with prescription data linkage

AU - Lakha, Fatim

AU - Theodoratou, Evropi

AU - Farrington, Susan M.

AU - Tenesa, Albert

AU - Cetnarskyj, Roseanne

AU - Din, Farhat V. N.

AU - Porteous, Mary E.

AU - Dunlop, Malcolm G.

AU - Campbell, Harry

PY - 2012/10/22

Y1 - 2012/10/22

N2 - Background: In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival.Methods: Analysis was carried out on 309 cases and 294 controls from the Scottish Study of Colorectal Cancer (SOCCS). Cox's hazard and logistic regression models were applied to investigate the association between statin use and CRC risk and survival.Results: In an adjusted logistic regression model, statins were found to show a statistically significant association for three of the four statin variables and were found to not show a statistically significant association with either all-cause or CRC-specific mortality (OR 0.49; 95%CI 0.49-1.36; p-value = 0.17 and OR 0.33; 95%CI 0.08-1.35; P-value = 0.12, respectively).Conclusion: We did find a statistically significant association between statin intake and CRC risk but not statin intake and CRC-specific mortality. However, the study was insufficiently powered and larger scale studies may be advisable.

AB - Background: In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival.Methods: Analysis was carried out on 309 cases and 294 controls from the Scottish Study of Colorectal Cancer (SOCCS). Cox's hazard and logistic regression models were applied to investigate the association between statin use and CRC risk and survival.Results: In an adjusted logistic regression model, statins were found to show a statistically significant association for three of the four statin variables and were found to not show a statistically significant association with either all-cause or CRC-specific mortality (OR 0.49; 95%CI 0.49-1.36; p-value = 0.17 and OR 0.33; 95%CI 0.08-1.35; P-value = 0.12, respectively).Conclusion: We did find a statistically significant association between statin intake and CRC risk but not statin intake and CRC-specific mortality. However, the study was insufficiently powered and larger scale studies may be advisable.

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Statin use and association with colorectal cancer survival and risk: Case control study with prescription data linkage

Abstract

ASJC Scopus subject areas

UN SDGs

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