Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity

Martina Pierri, Xingui Liu, Alena Kroupova, Zoe Rutter, Alex J. Hallatt, Alessio Ciulli (Lead / Corresponding author)

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Development of LRRK2 PROTAC degraders as chemical probes and potential lead compounds for the treatment of Parkinson’s disease (PROCESS)
Ciulli, A. (Investigator)
1/09/22 → 29/02/24
Project: Research
DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)
Ciulli, A. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/05/13 → 30/04/18
Project: Research