Stick it with VHL

William Farnaby

doi:10.1038/s41589-025-01897-1

Stick it with VHL

William Farnaby (Lead / Corresponding author)

Centre for Targeted Protein Degradation

Research output: Contribution to journal › Comment/debate › peer-review

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Abstract

Molecular glue degraders are small molecules that have major therapeutic potential. Here, protein microarrays enabled the identification of proteins that can be glued to the VHL E3 ligase and degraded with VHL targeting ligands.

Original language	English
Pages (from-to)	1644-1645
Number of pages	2
Journal	Nature Chemical Biology
Volume	21
Issue number	11
Early online date	24 Jun 2025
DOIs	https://doi.org/10.1038/s41589-025-01897-1
Publication status	Published - Nov 2025

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/s41589-025-01897-1

Author Accepted ManuscriptAccepted author manuscript, 144 KBLicence: Other

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title = "Stick it with VHL",

abstract = "Molecular glue degraders are small molecules that have major therapeutic potential. Here, protein microarrays enabled the identification of proteins that can be glued to the VHL E3 ligase and degraded with VHL targeting ligands.",

author = "William Farnaby",

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AB - Molecular glue degraders are small molecules that have major therapeutic potential. Here, protein microarrays enabled the identification of proteins that can be glued to the VHL E3 ligase and degraded with VHL targeting ligands.

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DO - 10.1038/s41589-025-01897-1

M3 - Comment/debate

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JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 11

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Stick it with VHL

Abstract

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