Stimulation of p21ras upon T-cell activation

Julian Downward, Jonathan D. Graves, Patricia H. Warne, Sydonia Rayter, Doreen A. Cantrell

Research output: Contribution to journalArticlepeer-review

677 Citations (Scopus)

Abstract

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalNature
Volume346
Issue number6286
DOIs
Publication statusPublished - 23 Aug 1990

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