Stimulation of p21ras upon T-cell activation

Julian Downward; Jonathan D. Graves; Patricia H. Warne; Sydonia Rayter; Doreen A. Cantrell

doi:10.1038/346719a0

Stimulation of p21^ras upon T-cell activation

Julian Downward
, Jonathan D. Graves
, Patricia H. Warne
, Sydonia Rayter
, Doreen A. Cantrell

Cell Signalling and Immunology

Research output: Contribution to journal › Article › peer-review

843 Citations (Scopus)

Abstract

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21^ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21^ras may therefore be an important mediator of the action of protein kinase C.

Original language	English
Pages (from-to)	719-723
Number of pages	5
Journal	Nature
Volume	346
Issue number	6286
DOIs	https://doi.org/10.1038/346719a0
Publication status	Published - 23 Aug 1990

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title = "Stimulation of p21ras upon T-cell activation",

abstract = "External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.",

author = "Julian Downward and Graves, \{Jonathan D.\} and Warne, \{Patricia H.\} and Sydonia Rayter and Cantrell, \{Doreen A.\}",

year = "1990",

month = aug,

day = "23",

doi = "10.1038/346719a0",

language = "English",

volume = "346",

pages = "719--723",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6286",

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TY - JOUR

T1 - Stimulation of p21ras upon T-cell activation

AU - Downward, Julian

AU - Graves, Jonathan D.

AU - Warne, Patricia H.

AU - Rayter, Sydonia

AU - Cantrell, Doreen A.

PY - 1990/8/23

Y1 - 1990/8/23

N2 - External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

AB - External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

UR - https://www.scopus.com/pages/publications/0025193117

U2 - 10.1038/346719a0

DO - 10.1038/346719a0

M3 - Article

C2 - 2201921

AN - SCOPUS:0025193117

SN - 0028-0836

VL - 346

SP - 719

EP - 723

JO - Nature

JF - Nature

IS - 6286

ER -

Stimulation of p21^ras upon T-cell activation

Abstract

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