Stochastic modelling of chromosomal segregation: errors can introduce correction

Anastasios Matzavinos (Lead / Corresponding author), Blerta Shtylla, Zachary Voller, Sijia Liu, Mark A.J. Chaplain

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer. During mitosis, chromosomal segregation is one such process that is crucial for successful progression. Accurate segregation of chromosomes during mitosis requires regulation of the interactions between chromosomes and spindle microtubules. If left uncorrected, chromosome attachment errors can cause chromosome segregation defects which have serious effects on cell fates. In early prometaphase, where kinetochores are exposed to multiple microtubules originating from the two poles, there are frequent errors in kinetochore-microtubule attachment. Erroneous attachments are classified into two categories, syntelic and merotelic. In this paper, we consider a stochastic model for a possible function of syntelic and merotelic kinetochores, and we provide theoretical evidence that merotely can contribute to lessening the stochastic noise in the time for completion of the mitotic process in eukaryotic cells.
    Original languageEnglish
    Pages (from-to)1590-1606
    Number of pages17
    JournalBulletin of Mathematical Biology
    Volume76
    Issue number7
    Early online date13 May 2014
    DOIs
    Publication statusPublished - Jul 2014

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