TY - JOUR
T1 - Stochastic modelling of chromosomal segregation
T2 - errors can introduce correction
AU - Matzavinos, Anastasios
AU - Shtylla, Blerta
AU - Voller, Zachary
AU - Liu, Sijia
AU - Chaplain, Mark A.J.
PY - 2014/7
Y1 - 2014/7
N2 - Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer. During mitosis, chromosomal segregation is one such process that is crucial for successful progression. Accurate segregation of chromosomes during mitosis requires regulation of the interactions between chromosomes and spindle microtubules. If left uncorrected, chromosome attachment errors can cause chromosome segregation defects which have serious effects on cell fates. In early prometaphase, where kinetochores are exposed to multiple microtubules originating from the two poles, there are frequent errors in kinetochore-microtubule attachment. Erroneous attachments are classified into two categories, syntelic and merotelic. In this paper, we consider a stochastic model for a possible function of syntelic and merotelic kinetochores, and we provide theoretical evidence that merotely can contribute to lessening the stochastic noise in the time for completion of the mitotic process in eukaryotic cells.
AB - Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer. During mitosis, chromosomal segregation is one such process that is crucial for successful progression. Accurate segregation of chromosomes during mitosis requires regulation of the interactions between chromosomes and spindle microtubules. If left uncorrected, chromosome attachment errors can cause chromosome segregation defects which have serious effects on cell fates. In early prometaphase, where kinetochores are exposed to multiple microtubules originating from the two poles, there are frequent errors in kinetochore-microtubule attachment. Erroneous attachments are classified into two categories, syntelic and merotelic. In this paper, we consider a stochastic model for a possible function of syntelic and merotelic kinetochores, and we provide theoretical evidence that merotely can contribute to lessening the stochastic noise in the time for completion of the mitotic process in eukaryotic cells.
UR - http://www.scopus.com/inward/record.url?scp=84901531344&partnerID=8YFLogxK
U2 - 10.1007/s11538-014-9969-z
DO - 10.1007/s11538-014-9969-z
M3 - Article
C2 - 24819688
SN - 0092-8240
VL - 76
SP - 1590
EP - 1606
JO - Bulletin of Mathematical Biology
JF - Bulletin of Mathematical Biology
IS - 7
ER -
