Strive or thrive: trends in Phytophthora capsici gene expression in partially resistant pepper

Gaëtan Maillot, Emmanuel Szadkowski, Anne Massire, Véronique Brunaud, Guillem Rigaill, Bernard Caromel, Joël Chadoeuf, Alexandre Bachellez, Nasradin Touhami, Ingo Hein, Kurt Lamour, Sandrine Balzergue, Véronique Lefebvre (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
37 Downloads (Pure)


Partial resistance in plants generally exerts a low selective pressure on pathogens, and thus ensuring their durability in agrosystems. However, little is known about the effect of partial resistance on the molecular mechanisms of pathogenicity, a knowledge that could advance plant breeding for sustainable plant health. Here we investigate the gene expression of Phytophthora capsici during infection of pepper (Capsicum annuum L.), where only partial genetic resistance is reported, using Illumina RNA-seq. Comparison of transcriptomes of P. capsici infecting susceptible and partially resistant peppers identified a small number of genes that redirected its own resources into lipid biosynthesis to subsist on partially resistant plants. The adapted and non-adapted isolates of P. capsici differed in expression of genes involved in nucleic acid synthesis and transporters. Transient ectopic expression of the RxLR effector genes CUST_2407 and CUST_16519 in pepper lines differing in resistance levels revealed specific host-isolate interactions that either triggered local necrotic lesions (hypersensitive response or HR) or elicited leave abscission (extreme resistance or ER), preventing the spread of the pathogen to healthy tissue. Although these effectors did not unequivocally explain the quantitative host resistance, our findings highlight the importance of plant genes limiting nutrient resources to select pepper cultivars with sustainable resistance to P. capsici.

Original languageEnglish
Article number980587
Number of pages19
JournalFrontiers in Plant Science
Early online date21 Nov 2022
Publication statusPublished - 21 Nov 2022


  • Capsicum annuum
  • Phytophthora capsici
  • RXLR effector
  • partial plant resistance
  • pathogen adaptation
  • transcriptomics

ASJC Scopus subject areas

  • Plant Science


Dive into the research topics of 'Strive or thrive: trends in Phytophthora capsici gene expression in partially resistant pepper'. Together they form a unique fingerprint.

Cite this