Structural basis of PROTAC cooperative recognition for selective protein degradation

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  Bump-BET; Bump and Hole Approach to Ellucidate Function of Individual Bromodomains of BET Proteins (Marie Curie Fellowship)

  Chan, K. H. (Investigator) & Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/10/15 → 30/09/17

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Protein Catabolism 92%
  • Proteolysis 83%
  • Bromodomain 73%
  • Protein Degradation 57%

• DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

  Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/13 → 30/04/18

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Ubiquitin-Conjugating Enzyme 88%
  • Proteolysis 84%
  • Ubiquitin Ligase 70%
  • Von Hippel-Lindau 62%

• A Systems Approach for the Fragment-based Development of Selective Chemical Probes of Bromodomain Function (joint with University of Oxford)

  Ciulli, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/04/13 → 7/06/15

  Project: Research

  • Bromodomain 100%
  • Small Molecule 56%
  • Chemical Probes 49%
  • Bromodomain-containing Protein 4 (BRD4) 44%
  • Proteolysis Targeting chimera (PROTAC) 40%