Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres

Ulrike Weinhart; Jerry R. Thomas; Yunbae Pak; Guy A. Thompson Jnr.; Michael A. J. Ferguson

Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres

Ulrike Weinhart, Jerry R. Thomas, Yunbae Pak, Guy A. Thompson Jnr., Michael A. J. Ferguson

University of Dundee

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A glycolipid metabolically labelled with [¹⁴C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Mana1-2Mana1-3Mana1-4GlcN glycan. The Tetrahymena glycolipid is structurally unique among the glycosylphosphatidylinositols that have so far been characterized, including those from several protozoan parasites of humans.

Original language	English
Pages (from-to)	605-608
Number of pages	4
Journal	Biochemical Journal
Volume	279
Issue number	2
Publication status	Published - 15 Oct 1991

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http://www.biochemj.org/bj/279/bj2790605.htm

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title = "Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres",

abstract = "A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Mana1-2Mana1-3Mana1-4GlcN glycan. The Tetrahymena glycolipid is structurally unique among the glycosylphosphatidylinositols that have so far been characterized, including those from several protozoan parasites of humans.",

author = "Ulrike Weinhart and Thomas, {Jerry R.} and Yunbae Pak and {Thompson Jnr.}, {Guy A.} and Ferguson, {Michael A. J.}",

year = "1991",

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T1 - Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres

AU - Weinhart, Ulrike

AU - Thomas, Jerry R.

AU - Pak, Yunbae

AU - Thompson Jnr., Guy A.

AU - Ferguson, Michael A. J.

PY - 1991/10/15

Y1 - 1991/10/15

N2 - A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Mana1-2Mana1-3Mana1-4GlcN glycan. The Tetrahymena glycolipid is structurally unique among the glycosylphosphatidylinositols that have so far been characterized, including those from several protozoan parasites of humans.

AB - A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Mana1-2Mana1-3Mana1-4GlcN glycan. The Tetrahymena glycolipid is structurally unique among the glycosylphosphatidylinositols that have so far been characterized, including those from several protozoan parasites of humans.

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M3 - Article

AN - SCOPUS:0025992449

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SP - 605

EP - 608

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -

Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres

Abstract

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