Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres

Ulrike Weinhart, Jerry R. Thomas, Yunbae Pak, Guy A. Thompson Jnr., Michael A. J. Ferguson

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Mana1-2Mana1-3Mana1-4GlcN glycan. The Tetrahymena glycolipid is structurally unique among the glycosylphosphatidylinositols that have so far been characterized, including those from several protozoan parasites of humans.

    Original languageEnglish
    Pages (from-to)605-608
    Number of pages4
    JournalBiochemical Journal
    Volume279
    Issue number2
    Publication statusPublished - 15 Oct 1991

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