TY - JOUR
T1 - Structural markers for normal oral mucosa and oral sub-mucous fibrosis
AU - Mookiah, Muthu Rama Krishnan
AU - Shah, P.
AU - Pal, M.
AU - Chakraborty, Chandan
AU - Paul, R.R.
AU - Chatterjee, J.
AU - Ray, A.K.
PY - 2010/6
Y1 - 2010/6
N2 - This article presents a quantitative approach for the characterization of normal oral mucosa (NOM) in respect to thickness and textural properties of its entire epithelial layer. Histological images of oral mucosa depict that both thickness and tissue architecture at cellular and tissue level undergo change, as mucosa converts from normal to precancerous or cancerous state. In this study the thickness and fractal dimension of the mucosal epithelium of NOM and oral sub-mucous fibrosis (OSF) condition have been computed using 83 normal and 29 OSF images of oral mucosa. The result shows significant delineation between NOM and OSF in respect of both the epithelial thickness (in μm) and fractal dimensions. This quantitative characterization of oral epithelium will be of immense help for oral onco-pathologists and researchers to assess the biological nature of normal and diseased (OSF) mucosa with higher accuracy. Moreover, further differential applications may enable them to find out newer accurate quantitative diagnostic procedures to that of the usual histopathological gold standard for the assessment of malignant potentiality.
AB - This article presents a quantitative approach for the characterization of normal oral mucosa (NOM) in respect to thickness and textural properties of its entire epithelial layer. Histological images of oral mucosa depict that both thickness and tissue architecture at cellular and tissue level undergo change, as mucosa converts from normal to precancerous or cancerous state. In this study the thickness and fractal dimension of the mucosal epithelium of NOM and oral sub-mucous fibrosis (OSF) condition have been computed using 83 normal and 29 OSF images of oral mucosa. The result shows significant delineation between NOM and OSF in respect of both the epithelial thickness (in μm) and fractal dimensions. This quantitative characterization of oral epithelium will be of immense help for oral onco-pathologists and researchers to assess the biological nature of normal and diseased (OSF) mucosa with higher accuracy. Moreover, further differential applications may enable them to find out newer accurate quantitative diagnostic procedures to that of the usual histopathological gold standard for the assessment of malignant potentiality.
KW - Normal oral mucosa (NOM)
KW - Oral sub-mucous fibrosis (OSF)
KW - Fractal analysis
KW - Dysplasia
KW - Light microscopy
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-77949487142&partnerID=MN8TOARS
U2 - 10.1016/j.micron.2009.12.002
DO - 10.1016/j.micron.2009.12.002
M3 - Article
VL - 41
SP - 312
EP - 320
JO - Micron
JF - Micron
IS - 4
ER -