Structural transition of the nucleosome during chromatin remodeling and transcription

Wataru Kobayashi; Hitoshi Kurumizaka

doi:10.1016/j.sbi.2019.07.011

Structural transition of the nucleosome during chromatin remodeling and transcription

Wataru Kobayashi, Hitoshi Kurumizaka (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

In eukaryotes, the nucleosome is the basic unit of chromatin. Since the genomic DNA is tightly wrapped around the histone octamer in the nucleosome, its function is severely restricted in chromatin. To overcome the nucleosome barrier, the nucleosome structure must dynamically change during genomic DNA functions. Recent structural studies revealed that chromatin remodelers and RNA polymerase II drastically alter the nucleosome structures during the chromatin remodeling and transcription processes. These results provide important information for understanding how genes are properly regulated in eukaryotes. Here, we review the recent structural studies of nucleosome versatility and dynamics during chromatin remodeling and transcription by RNA polymerase II.

Original language	English
Pages (from-to)	107-114
Number of pages	8
Journal	Current Opinion in Structural Biology
Volume	59
DOIs	https://doi.org/10.1016/j.sbi.2019.07.011
Publication status	Published - Dec 2019

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title = "Structural transition of the nucleosome during chromatin remodeling and transcription",

abstract = "In eukaryotes, the nucleosome is the basic unit of chromatin. Since the genomic DNA is tightly wrapped around the histone octamer in the nucleosome, its function is severely restricted in chromatin. To overcome the nucleosome barrier, the nucleosome structure must dynamically change during genomic DNA functions. Recent structural studies revealed that chromatin remodelers and RNA polymerase II drastically alter the nucleosome structures during the chromatin remodeling and transcription processes. These results provide important information for understanding how genes are properly regulated in eukaryotes. Here, we review the recent structural studies of nucleosome versatility and dynamics during chromatin remodeling and transcription by RNA polymerase II.",

author = "Wataru Kobayashi and Hitoshi Kurumizaka",

year = "2019",

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doi = "10.1016/j.sbi.2019.07.011",

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volume = "59",

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journal = "Current Opinion in Structural Biology",

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T1 - Structural transition of the nucleosome during chromatin remodeling and transcription

AU - Kobayashi, Wataru

AU - Kurumizaka, Hitoshi

PY - 2019/12

Y1 - 2019/12

N2 - In eukaryotes, the nucleosome is the basic unit of chromatin. Since the genomic DNA is tightly wrapped around the histone octamer in the nucleosome, its function is severely restricted in chromatin. To overcome the nucleosome barrier, the nucleosome structure must dynamically change during genomic DNA functions. Recent structural studies revealed that chromatin remodelers and RNA polymerase II drastically alter the nucleosome structures during the chromatin remodeling and transcription processes. These results provide important information for understanding how genes are properly regulated in eukaryotes. Here, we review the recent structural studies of nucleosome versatility and dynamics during chromatin remodeling and transcription by RNA polymerase II.

AB - In eukaryotes, the nucleosome is the basic unit of chromatin. Since the genomic DNA is tightly wrapped around the histone octamer in the nucleosome, its function is severely restricted in chromatin. To overcome the nucleosome barrier, the nucleosome structure must dynamically change during genomic DNA functions. Recent structural studies revealed that chromatin remodelers and RNA polymerase II drastically alter the nucleosome structures during the chromatin remodeling and transcription processes. These results provide important information for understanding how genes are properly regulated in eukaryotes. Here, we review the recent structural studies of nucleosome versatility and dynamics during chromatin remodeling and transcription by RNA polymerase II.

UR - http://dx.doi.org/10.1016/j.sbi.2019.07.011

U2 - 10.1016/j.sbi.2019.07.011

DO - 10.1016/j.sbi.2019.07.011

M3 - Article

SN - 0959-440X

VL - 59

SP - 107

EP - 114

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -

Structural transition of the nucleosome during chromatin remodeling and transcription

Abstract

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