Structure and function in the nucleus

Angus I. Lamond, William C. Earnshaw

Research output: Contribution to journalReview article

748 Citations (Scopus)

Abstract

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

Original languageEnglish
Pages (from-to)547-553
Number of pages7
JournalScience
Volume280
Issue number5363
DOIs
Publication statusPublished - 24 Apr 1998

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