Structure and function in the nucleus

Angus I. Lamond; William C. Earnshaw

doi:10.1126/science.280.5363.547

Structure and function in the nucleus

Angus I. Lamond, William C. Earnshaw

Research output: Contribution to journal › Review article › peer-review

805 Citations (Scopus)

Abstract

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

Original language	English
Pages (from-to)	547-553
Number of pages	7
Journal	Science
Volume	280
Issue number	5363
DOIs	https://doi.org/10.1126/science.280.5363.547
Publication status	Published - 24 Apr 1998

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10.1126/science.280.5363.547

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AB - Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

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Structure and function in the nucleus

Abstract

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