Structure and function of ribosomal RNA gene chromatin

Joanna L. Birch, Joost C. B. M. Zomerdijk

    Research output: Contribution to journalArticlepeer-review

    44 Citations (Scopus)

    Abstract

    Transcription of the major ribosomal RNAs by Pol I (RNA polymerase 1) is a key determinant of ribosome biogenesis, driving cell growth and proliferation in eukaryotes. Hundreds of copies of rRNA genes are present in each cell, and there is evidence that the cellular control of Pol I transcription involves adjustments to the number of rRNA genes actively engaged in transcription, as well as to the rate of transcription from each active gene. Chromatin structure is inextricably linked to rRNA gene activity, and the present review highlights recent advances in this area.

    Original languageEnglish
    Pages (from-to)619-624
    Number of pages6
    JournalBiochemical Society Transactions
    Volume36
    DOIs
    Publication statusPublished - Aug 2008

    Keywords

    • chromatin
    • chromatin remodelling
    • nucleosome
    • ribosomal DNA (rDNA)
    • rRNA gene
    • RNA polymerase 1
    • transcription
    • POLYMERASE-I TRANSCRIPTION
    • REMODELING COMPLEX NORC
    • UPSTREAM BINDING-FACTOR
    • SACCHAROMYCES-CEREVISIAE
    • NUCLEOLAR DOMINANCE
    • HISTONE CHAPERONE
    • DNA METHYLATION
    • GROWTH-CONTROL
    • PROTEIN GENES
    • RDNA

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