Structure and function of ribosomal RNA gene chromatin

Joanna L. Birch; Joost C. B. M. Zomerdijk

doi:10.1042/BST0360619

Structure and function of ribosomal RNA gene chromatin

Joanna L. Birch, Joost C. B. M. Zomerdijk

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Transcription of the major ribosomal RNAs by Pol I (RNA polymerase 1) is a key determinant of ribosome biogenesis, driving cell growth and proliferation in eukaryotes. Hundreds of copies of rRNA genes are present in each cell, and there is evidence that the cellular control of Pol I transcription involves adjustments to the number of rRNA genes actively engaged in transcription, as well as to the rate of transcription from each active gene. Chromatin structure is inextricably linked to rRNA gene activity, and the present review highlights recent advances in this area.

Original language	English
Pages (from-to)	619-624
Number of pages	6
Journal	Biochemical Society Transactions
Volume	36
DOIs	https://doi.org/10.1042/BST0360619
Publication status	Published - Aug 2008

Keywords

chromatin
chromatin remodelling
nucleosome
ribosomal DNA (rDNA)
rRNA gene
RNA polymerase 1
transcription
POLYMERASE-I TRANSCRIPTION
REMODELING COMPLEX NORC
UPSTREAM BINDING-FACTOR
SACCHAROMYCES-CEREVISIAE
NUCLEOLAR DOMINANCE
HISTONE CHAPERONE
DNA METHYLATION
GROWTH-CONTROL
PROTEIN GENES
RDNA

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title = "Structure and function of ribosomal RNA gene chromatin",

abstract = "Transcription of the major ribosomal RNAs by Pol I (RNA polymerase 1) is a key determinant of ribosome biogenesis, driving cell growth and proliferation in eukaryotes. Hundreds of copies of rRNA genes are present in each cell, and there is evidence that the cellular control of Pol I transcription involves adjustments to the number of rRNA genes actively engaged in transcription, as well as to the rate of transcription from each active gene. Chromatin structure is inextricably linked to rRNA gene activity, and the present review highlights recent advances in this area.",

keywords = "chromatin, chromatin remodelling, nucleosome, ribosomal DNA (rDNA), rRNA gene, RNA polymerase 1, transcription, POLYMERASE-I TRANSCRIPTION, REMODELING COMPLEX NORC, UPSTREAM BINDING-FACTOR, SACCHAROMYCES-CEREVISIAE, NUCLEOLAR DOMINANCE, HISTONE CHAPERONE, DNA METHYLATION, GROWTH-CONTROL, PROTEIN GENES, RDNA",

author = "Birch, {Joanna L.} and Zomerdijk, {Joost C. B. M.}",

year = "2008",

month = aug,

doi = "10.1042/BST0360619",

language = "English",

volume = "36",

pages = "619--624",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press",

}

TY - JOUR

T1 - Structure and function of ribosomal RNA gene chromatin

AU - Birch, Joanna L.

AU - Zomerdijk, Joost C. B. M.

PY - 2008/8

Y1 - 2008/8

N2 - Transcription of the major ribosomal RNAs by Pol I (RNA polymerase 1) is a key determinant of ribosome biogenesis, driving cell growth and proliferation in eukaryotes. Hundreds of copies of rRNA genes are present in each cell, and there is evidence that the cellular control of Pol I transcription involves adjustments to the number of rRNA genes actively engaged in transcription, as well as to the rate of transcription from each active gene. Chromatin structure is inextricably linked to rRNA gene activity, and the present review highlights recent advances in this area.

AB - Transcription of the major ribosomal RNAs by Pol I (RNA polymerase 1) is a key determinant of ribosome biogenesis, driving cell growth and proliferation in eukaryotes. Hundreds of copies of rRNA genes are present in each cell, and there is evidence that the cellular control of Pol I transcription involves adjustments to the number of rRNA genes actively engaged in transcription, as well as to the rate of transcription from each active gene. Chromatin structure is inextricably linked to rRNA gene activity, and the present review highlights recent advances in this area.

KW - chromatin

KW - chromatin remodelling

KW - nucleosome

KW - ribosomal DNA (rDNA)

KW - rRNA gene

KW - RNA polymerase 1

KW - transcription

KW - POLYMERASE-I TRANSCRIPTION

KW - REMODELING COMPLEX NORC

KW - UPSTREAM BINDING-FACTOR

KW - SACCHAROMYCES-CEREVISIAE

KW - NUCLEOLAR DOMINANCE

KW - HISTONE CHAPERONE

KW - DNA METHYLATION

KW - GROWTH-CONTROL

KW - PROTEIN GENES

KW - RDNA

U2 - 10.1042/BST0360619

DO - 10.1042/BST0360619

M3 - Article

C2 - 18631128

SN - 0300-5127

VL - 36

SP - 619

EP - 624

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

ER -

Structure and function of ribosomal RNA gene chromatin

Abstract

Keywords

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