Keyphrases
Active Adjustment
33%
Active Sites
66%
African Trypanosomiasis
33%
Alpha6
66%
Amino Acid Sequence
33%
Amino Acid Variation
33%
Antifolate
100%
Binding Cleft
33%
Broad-spectrum Activity
33%
C-terminus
33%
Carboxyl Group
33%
Catalytic Center
33%
Catalytic Properties
33%
Chemical Properties
33%
Cofactor-binding Site
33%
Cysteine Protease
33%
Folate
33%
Helix
33%
Leishmania Major
66%
Metabolic Bypass
33%
Methotrexate
100%
Methylenetetrahydrofolate Reductase (MTHFR)
33%
NADP+
33%
Nicotinamide Adenine Dinucleotide Phosphate (NADPH)
33%
Parasite Growth
33%
Pteridine Reductase 1
100%
Pterin
66%
PTR1
100%
Recombinant
33%
Reductase
33%
Sequence Identity
33%
Short Chain
33%
Structural Features
33%
Substrate Binding
33%
Substrate Binding Site
33%
Ternary Complex
33%
Therapeutic Value
33%
Trypanosoma Brucei
100%
Trypanosomatids
33%
Trypanosomiasis
33%
Biochemistry, Genetics and Molecular Biology
Active Site
66%
Amino Acids
33%
Antifolate
100%
Binding Site
66%
C-Terminus
33%
Crystal Structure
33%
Cysteine Protease
33%
Dihydrofolate Reductase
33%
Enzyme
33%
Leishmania Major
66%
Methotrexate
100%
Nicotinamide Adenine Dinucleotide Phosphate
33%
Oxidoreductase
100%
Peptide Sequence
33%
Protozoon
33%
Reductase
100%
Ternary Complex
33%
Trypanosoma Brucei
100%
Trypanosomatidae
33%